T Creams vs. injections and Prostate

stcrim

New Member
This may be N=1 but I'll ask the question as though other people have the issue too. Why do compounded bio-identical testosterone creams cause more prostate or prostate like symptoms than T injections?

I am really fond of the idea of creams since they don't raise the red blood cell count to the extent injections to. I am a DVT/PE survivor and prefer to keep to that way. Even though when injecting I do so two to three times per week, creams are less of a rollercoaster.

Has anyone else used creams and had issues with frequent nighttime urination and/or difficulty starting?
 
Topical testosterone can have a more of a tendency to convert to higher amounts of DHT than the injectable forms. Both injectable and topical testosterones use the same raw material to compound/manufacture, so both are technically bio-identical in its raw form.

When DHT becomes too elevated it can inflame the prostate in some men who are especially sensitive to this effect. You can talk to you doctor about follow up testing to check DHT and SHBG levels, in addition to T and E. Dosage may be too high and/or you may be a high absorber of topical hormones.
 
Jason, thank you for your response! It usually only takes a day or two for symptoms to show up on creams. I stopped injections and started using the cream in a different location (rectally) about 10 days ago and at this point am having no issues. The absorption must be excellent there because I have had to reduce my dose (long story). From reading what I can about it, this may be the way to go with creams...
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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