Sustained, slow-release, T3. Have you tried it? Thoughts?

raginghormone

New Member
Has anyone tried it and felt best on it? I have a strong suspicion that high dosages of T3 at once tend to drive up mens' SHBG and lower testosterone, having deleterious consequences. Even NDT twice a day can be considered high. Women probably aren't as susceptible to this.
Perhaps slow-release T3 is better for men? I'd love to collect some data points. I know that there are swaths of people out there who don't do well on it--wondering if demographics have an effect on it.
 
I know form seeing what happens to someone that takes T3 that how its administered effects the result. Taking a large dose all at one time is dramatically different than splitting that dose up through the day. You can overdose on the one time dose yet feel nothing on the same amount divided through the day. If you look at the Pfizer prescribing info it would lead you to believe that divided doses are not needed. The half life is short but the effects last much longer. When overdosed it took a good day and a half to get back to normal after not taking anymore. So the use of slow release to me is not needed. There is probably a use for it I don't know.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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