Sub Cuetaneous Transition

TDM812

Member
I have been battling high estrogen, for a few months. After posting my challenges on here, I received great advice - split my dose of 140 weekly, in 2 - 70 mg doses. I started out by doing .35 dex at injection time and I tanked, went to .25 tanked, so this week I didn’t take any with injections and my nighttime erections came back sostring they put a California Redwood to shame. So, I think my estrogen mystery has been solved. Now my problem is fatigue, weak, and I have “snapped” a couple times over stupid stuff. I had labs pulled on Thursday, but I won’t get results until next week. Anyone care to hazard a guess as to what the problem is now? I made the sub q split about 3 weeks ago.
 
I have been battling high estrogen, for a few months. After posting my challenges on here, I received great advice - split my dose of 140 weekly, in 2 - 70 mg doses. I started out by doing .35 dex at injection time and I tanked, went to .25 tanked, so this week I didn’t take any with injections and my nighttime erections came back sostring they put a California Redwood to shame. So, I think my estrogen mystery has been solved. Now my problem is fatigue, weak, and I have “snapped” a couple times over stupid stuff. I had labs pulled on Thursday, but I won’t get results until next week. Anyone care to hazard a guess as to what the problem is now? I made the sub q split about 3 weeks ago.



You need labs posted for anyone to even know where your TT/FT and e2 (sensitive assay) levels sit on such a protocol.

What are your SHBG levels?
 
Good call - I will pull my last labs. How long does it take to adjust/stabilize when switching to split dose ?
Your levels should stabilize in 6 weeks after adjusting protocol. I like to wait 12 weeks, it takes me that long before I can feel the difference.
 
You're taking to big of a swing at too many things to know whats going on, splitting dose, taking .35 and then .25mg, you've done too much at one-time and all this speculation isn't helpful to you or any one else that is reading it. You need to follow the advice that was given to you...6 weeks and stop playing with your doses and frequency.
 
You're taking to big of a swing at too many things to know whats going on, splitting dose, taking .35 and then .25mg, you've done too much at one-time and all this speculation isn't helpful to you or any one else that is reading it. You need to follow the advice that was given to you...6 weeks and stop playing with your doses and frequency.
Yep Vince Carter is right. Take it slow, like so many member say. Trt is a marathon, not a Sprint.
 
I received partial labs today:

Quest Diagnostics
1.61 Free
776 Total
18 Estradiol

This was exactly 3 days after my last .70 injection, and .35 adex. At the time of lab work I have been on .7 x2 weekly for about 3 weeks.

Looks like a pretty big drop in test free/total. Wouldn’t this cause fatigue, weakness, etc.?

Labs prior to this on a 140mg 1 time weekly:
2.01 free
1203 total
<15 estradiol
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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