Study for Prostate Cancer Survivors

madman

Super Moderator

Brigham and Women's Hospital is conducting this study to research whether testosterone replacement therapy improves the quality of life for men who have undergone prostate removal for prostate cancer.


Overview

What we are studying


The purpose of this study is to evaluate the safety and efficacy of testosterone replacement therapy in men, who have undergone prostate removal for prostate cancer. Investigators are studying whether testosterone replacement therapy is beneficial and safe in improving sexual function, health-related quality of life, muscle mass, and muscle strength.


Why is it important

Men who have undergone prostate removal for prostate cancer often experience sexual dysfunction and low energy which are important contributors to quality of life. Testosterone replacement therapy may improve these symptoms in prostate cancer survivors, and ultimately, improve their quality of life.


What we hope to accomplish

The research hopes to determine the safety and efficacy of Testosterone replacement therapy in improving sexual function in men who have undergone radical prostatectomy for prostate cancer. We will enroll prostate cancer survivors, who will receive either testosterone or a placebo and closely monitor their health throughout the study.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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