Studies supporting efficacy of low dose clomid in the treatment of secondary hypogonadism

Forty2

Active Member
Is anyone aware of any studies that have been done on clomid using a dose as low as 12.5mg eod?
I've read so many accounts both here and on other forums from guys who have increased their TT and FT to near the top of the normal reference range on such a low dose, but I've been unable to find any published studies supporting the efficacy of such a low dose.
 
You may have read this already, it's a good thread by Dr. Saya.

Are guys that do well on low dose clomid unicorns...or do they really exist?

https://www.excelmale.com/forum/sho...-dose-clomid-unicorns-or-do-they-really-exist

Yes you gave a link to this thread in my other post. Once again, it did not answer my question.
If I'm not mistaken, Dr Eugene Shippen was the first doctor who tried clomid doses as low as 12.5mg eod and then Crisler and other doctors such as Dr Saya followed suit.
I'd still like to see a study with a dose this low that I can show my endo, because his belief is that 50mg eod is the best dose for everyone!
 
Personally, I think a lot of TRT doctors learn what works and doesn't work, by trying different treatments on patients that are having struggles with current protocols.
 
It will be something of a surprise of you find any peer-reviewed studies on point. The leading clinicians are in many cases years and years ahead of the journals. What works in practice is seen in more and more clinical situations, discussed at conferences, and then - finally - comes to the attention of academic medicine where, in time, a study will confirm what leading practitioners have been doing for years.
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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