Split dosage

[Robert Frank Fields]

I am prescribed 250ml of Testosterone cypronate? every 21 days. Would this be best split in 2 doses every week and a half?

 

[Tom Larabee]

3 doses every week or 6 doses done twice every week would be better break downs of the original dosage from a Doctor who clearly doesn't know the half-life of Cyp.

 

[Superman]

get a new doctor OP.

its scary that doctors are still doing 21 days between shots.

 

[ERO]

Seriously, not to sound rude - but you need a doctor that understands TRT and the half life of cyp.

In the meantime, try 50 mg of Test every 3.5 days. So like Monday morning and Thursday evening, for example.

 

[CoastWatcher]

A noted, you have a doctor who is clearly unfamiliar with current TRT protocols - to say nothing of not understanding the half-life of testosterone delivered via injection. Should you follow the prescribed protocol, you are going to feel miserable.

 

[Vince]

I agree 21 days is way too far apart, I also inject every 3 1/2 days.

 

[Gene Devine]

Love it!!!!

Glade to see such good advice from members here..."our" forum is growing boys!!!

Keep up the good work and good advice

G

 

[Nelson Vergel]

Robert

Negotiate with your doctor to allow you to use 100 mg per week, retest at week 6 and readjust dose based on a total testosterone blood value of at least 500 ng/dL or more (right before the next dose).

Show him this graph from my book Built to Survive.

Source: Schulte-Beerbuhl, 1980 Figure. Pharmacokinetics of 200mg Testosterone cypionate injection. Source: Comparison of Testosterone, dihydrotestosterone, luteinizing hormone, and follicle-stimulating hormone in serum after injection of Testosterone enanthate or Testosterone cypionate. Schulte-Beerbuhl M, Nieschlag E. Fertility and Sterility 33 (1980) 201-3.



After 10 days of a 200 mg injection, T levels go back to baseline. How can expect 250 mg to cover you for 21 days?

 

[James]

Nelson/Gene (or anyone else) - Would you clear something up for me. If after 10 days your T levels go back to baseline, yet the majority of sites say the half life of cypionate is 8 - 12 days based on how quickly the individual metabolizes the medication, wouldn't that mean 1/2 the cypionate is still being used by your body (potentially on day 10 or 12)? Are these sites wrong? And if so, I suppose if Docs believe the 1/2 life to be 10 or 12 days, then it would make sense for them to dose every 21 days. I've got lower/normal SHBG, so I feel like my 1/2 life is closer to 2 days. Seems like a big difference of opinion on this topic (and the topic of E2 management), by some very knowledgeable individuals and docs who claim to be cutting edge and specialize in TRT. What am I missing here?

 

[ERO]

It gets confusing because the half-life is not the same as effective half-life. With TRT you want to try to have as steady a T level as possible rather than a huge roller coaster ride between 200mgs all at once and baseline (which by definition for us is low T - not a healthy level) after 10-days. To say it another way, yes, there is still *some* T left at 10 days - but not an effective dose that will make you feel well and healthy. This is why many guys dose every 3.5 days. Less change between peak and trough, less conversion to E2, steadier T levels = you feel better. If you inject with an insulin syringe sub-Q you won't even feel the shot, so injecting more often is not painful or a hardship.

This is not a perfect analogy, but think of pain medication as an example. If you broke your leg, and the doc set it and put it in a cast to heal and sent you home, would you want to take 50 aspirin at once to hold you for the next week, or would you want to take 2 aspirin every 4 hours to keep an steady, effective dose going?