Significant Loss of Orgasm Sensation from Very Low E2?

[DaytonaJonah]

Taking the advice of my HRT doctor addressing my high E2 numbers from my last tests...75, she prescribed for me to take .25mgs of Arimidex 2x's weekly to see if my numbers could fall into the range of 15-20. However, from my past experience having crushed my E2 to <5, I decided to only take .125mgs 2x's per week to see if I could SLOWLY approach this range she's suggesting.
Well, after 2 weeks now on this new protocol(reduced as it is), my joints are killing me, and I am experiencing a very distressing event during sex...a nearly complete loss of any sensation during orgasm! I take 10mgs. EOD of Cialis to manage my BPH and to assist with erection strength and have been doing this for nearly a year now with no side effects whatsoever. Yet the new symptom has me questioning if my E2 is in the bottom of the tank and is severely affecting my penile sensitivity.

Went this morning to have my blood drawn to confirm or deny my suspicions.

Anyone else have a similar experience?

 

[bochinit]

Yes, low E2 and I dont even want to do anything in my day. Pênis will be half the size, boring orgams. Also depression feelings, like a suicide/niilist and lethargy.

Strangelly, less than 150mg Test per week and I feel like this..

 

[Stylo]

How were you feeling with E at 75? Great Im sure. This is insane! I Fluctuate around those numbers, Im sure maybe higher at times, and I wouldnt listen to the Doc who doesnt have a dick. Drop the AI and let your body do its thing. If you just started, itll be hard to really gauge things but once you rebound don’t take anymore AIs.

 

[DaytonaJonah]

How were you feeling with E at 75? Great Im sure. This is insane! I Fluctuate around those numbers, Im sure maybe higher at times, and I wouldnt listen to the Doc who doesnt have a dick. Drop the AI and let your body do its thing. If you just started, itll be hard to really gauge things but once you rebound don’t take anymore AIs.

With E at 75 I honestly didn't feel all that good. My libido was next to nothing...no sexual thoughts, no stirring in my penis seeing my naked wife, etc. I could get an erection just fine using Cialis, but the arousal+libido connection wasn't there. I normally run TT from 750 to 1100 using daily cream application. With E at 75 I was starting to have some sensitive nipples and experiencing some additional emotions that weren't my normal well-rounded jovial and good nature.
Thus, I am wanting to find my sweet-spot range because where I was at...wasn't it. I suspect that where I'm at now is sub 15 to possibly lower so I won't be taking anymore AI until I get back to the higher levels before. Then, I may try to lower my T dose to see if I can slip into a better libido/arousal range with enough T to still train with.

But, I want to isolate the issue I've just experienced with having nearly NO sensation of orgasm to having low E2. If others have experienced the same, then I can relax as I come out of the low E2 environment.

 

[Nelson Vergel]

Estradiol and Penile Sensitivity

Can anyone tell me what the relationship is between estrogen and penis sensitivity? What would be the result of high estrogen levels and what's likely to be the result of the low estrogen levels. Thanks guys.

www.excelmale.com

Anastrozole and joint pain

Hey Guys, Before I was on TRT I had mild joint pain. It wasn't enough to reach for pain meds, and it wasn't chronic. I treated it with taking a little extra fish oil and glucosamine tablets. Looking back I don't think those did much. Shortly after starting TRT I noticed the mild joint pain less...

www.excelmale.com

 

[Golfboy307]

Some guys on here have had some success microdosing AI's by dissolving them in vodka and then using small portions of the solution. I think Cataceous has posted on this in other threads. I don't know the amounts to use but just an FYI

 

[DaytonaJonah]

Some guys on here have had some success microdosing AI's by dissolving them in vodka and then using small portions of the solution. I think Cataceous has posted on this in other threads. I don't know the amounts to use but just an FYI

Once I get my E numbers back up and my equipment working better, I may attempt to do just this. I've experimented with dissolving a tablet of Arimidex in vodka and see that it is a bit non-scientific, but adding 2ml's to 1mg of AI gets it pretty close to a micro-dose amount that may be suitable to my body's sensitivity to it. .125 2x's a week appears to be too much for me, but I need my tests results back(by this Friday) so I can know where I'm at first.

 

[DaytonaJonah]

Estradiol and Penile Sensitivity

Can anyone tell me what the relationship is between estrogen and penis sensitivity? What would be the result of high estrogen levels and what's likely to be the result of the low estrogen levels. Thanks guys.

www.excelmale.com

Anastrozole and joint pain

Hey Guys, Before I was on TRT I had mild joint pain. It wasn't enough to reach for pain meds, and it wasn't chronic. I treated it with taking a little extra fish oil and glucosamine tablets. Looking back I don't think those did much. Shortly after starting TRT I noticed the mild joint pain less...

www.excelmale.com

Thanks Nelson...will take a look.

DJ

 

[Nelson Vergel]

I think blocking aromatization with anastrozole when you are on TRT (i.e., you do not have low testosterone), is as counterproductive as blocking DHT with finasteride.

I have been moderating this site for 11 years and I would say 90% of men using anastrozole are doing so based on what their ill trained physician told them, what they read online, or what they assumed were high estradiol symptoms. Most of them did not even test their estradiol and, if they did, started treatments with an AI because the LabCorp or Quest lab range told them they were high (lab ranges are based on men not on TRT).

There is no amount of information I can publish that can change this perception. I predict that it will take at least 10 more years to shift this perception that has taken hold based on poor data and a wrong assumption.

Some of you may say "but I feel better on anastrozole". If so, more power to you and stay on the drug.

Estradiol, like DHT, is an enhancer of testosterone. It is not a toxic hormone. Only 0.4 percent of testosterone aromatizes to estradiol. It is not the cause of moodiness, water retention, sore nipples, etc in men on TRT. I have over 30 articles about this on ExcelMale.com. Just google "Estradiol ExcelMale.com" to read a few.

I know many of you will push back to this statement. I am a broken record but I am starting to see the TRT field starting to shift while some clinics are still lagging behind in updated knowledge and data.

 

[Stylo]

Youre on the right track by adjusting your dose and frequency. AI is gonna get you again.

 

[Starplex]

Agreed Nelson. My doctor was would never give me an AI based on exactly what you described. So glad too. I've never taken an AI, my T is >1000, my E2 is a higher value and I feel great. Morning wood, always horny, will make love to the wife every chance she gives me. I struggle with HCT but it is manageable. Have desensitivity occasionally if I have much alcohol.

 

[Cataceous]

Some guys on here have had some success microdosing AI's by dissolving them in vodka and then using small portions of the solution. I think Cataceous has posted on this in other threads. I don't know the amounts to use but just an FYI

Not taking it at the moment, but I used 10 mL vodka per 1 mg tablet. Then each 0.1 mL is 10 mcg. For me 35 mcg daily would reduce estradiol by about 20 pg/mL. This is close to what the OP took, so it would show very high sensitivity if he managed to drop from 75 pg/mL into crashed territory.

 

[Deleted member 16042]

Once I get my E numbers back up and my equipment working better, I may attempt to do just this. I've experimented with dissolving a tablet of Arimidex in vodka and see that it is a bit non-scientific, but adding 2ml's to 1mg of AI gets it pretty close to a micro-dose amount that may be suitable to my body's sensitivity to it. .125 2x's a week appears to be too much for me, but I need my tests results back(by this Friday) so I can know where I'm at first.

10ml to 1mg dilution provides easy math and is very easy to measure. I used to take 0.06-0.07 mg EOD measured as 0.6-0.7 ml on luer tip syringe, no needle.