Sexual dysfunction post SSRI and 5-alpha reductase inhibitors

[madman]

Thread 'Post-SSRI Sexual Dysfunction (PSSD): 15 Years of Symptoms, Research & Biological Causes'

May 9, 2026

* It is hypothesized that: ED is in part from SSRI-induced increased intracavernosal oxygen radical formation causing diffuse erectile tissue fibrosis; and reduced sensation/orgasm/libido is from SSRI-induced altered CNS neuron, synapse and neurotransmitter function. Informed consent prior to use of SSRI is appropriate.


* Data at initial presentation included hormone blood tests, quantitative sensory testing involving vibration, warmth and cold perception threshold testing, and vascular testing using grayscale/duplex Doppler ultrasound (G/DUS) during pharmacologic...

• madman
• depression ed post ssri sexual dysfunction
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• Forum: When TRT Is Not Enough (ED, Libido, & More)