Sex steroids mediate discrete effects on HDL cholesterol efflux capacity and particle concentration in healthy men

madman

Super Moderator
Conclusion

Our findings support roles for both testosterone and estradiol in regulating HDL particle size and function in men. They suggest that changes in HDL-C consequent to testosterone deprivation may not be a reliable predictor of changes in HDL CEC, and perhaps, therefore, may not impact CVD risk through this mechanism. Additional work is essential to delineate pathways by which sex steroids may regulate HDL remodeling and function and thereby help clarify the respective roles of androgens and estrogens in influencing cardiovascular risk in men. Critically, too, clinical studies are needed to determine whether the present findings are similarly evident with sex steroid manipulation in clinical settings, including exogenous TRT for male hypogonadism, male hormonal contraceptive regimens, or androgen deprivation therapy for treatment of prostate cancer.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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