madman
Super Moderator
Conclusion
Our findings support roles for both testosterone and estradiol in regulating HDL particle size and function in men. They suggest that changes in HDL-C consequent to testosterone deprivation may not be a reliable predictor of changes in HDL CEC, and perhaps, therefore, may not impact CVD risk through this mechanism. Additional work is essential to delineate pathways by which sex steroids may regulate HDL remodeling and function and thereby help clarify the respective roles of androgens and estrogens in influencing cardiovascular risk in men. Critically, too, clinical studies are needed to determine whether the present findings are similarly evident with sex steroid manipulation in clinical settings, including exogenous TRT for male hypogonadism, male hormonal contraceptive regimens, or androgen deprivation therapy for treatment of prostate cancer.
Our findings support roles for both testosterone and estradiol in regulating HDL particle size and function in men. They suggest that changes in HDL-C consequent to testosterone deprivation may not be a reliable predictor of changes in HDL CEC, and perhaps, therefore, may not impact CVD risk through this mechanism. Additional work is essential to delineate pathways by which sex steroids may regulate HDL remodeling and function and thereby help clarify the respective roles of androgens and estrogens in influencing cardiovascular risk in men. Critically, too, clinical studies are needed to determine whether the present findings are similarly evident with sex steroid manipulation in clinical settings, including exogenous TRT for male hypogonadism, male hormonal contraceptive regimens, or androgen deprivation therapy for treatment of prostate cancer.
