Setting Expectations

Ribeye

Active Member
I am approximately 2 months post starting T replacement therapy. My testosterone, was typically, in the low 300 range, having been tested 4 times prior to starting therapy. I am also hypo thyroid (Hashimoto's) and was taking Synthroid with corresponding levels that were "supposedly" in the middle of the therapeutic range, although I was very symptomatic of low thyroid and low T. I was switched over to NP thyroid 120 mg, at the same time I started the testosterone bio identical cream with 200 MG/gram compounded, taking 1/2 gram or 100 MG T twice a day. I was instructed to apply the cream directly to my scrotum. My understanding was, that would give me the best shot at boosting DHT which should help alleviate some of the low T symptoms more quickly (low libido for example). I was just given an increased dose of the T cream, again to apply to the scrotum. so, I am now taking for the last 4-5 days 3/4 gram twice a day, or about 150 MG T twice a day. In the first week, 4-5 days post starting treatment, I felt an incredible difference!! Nearly all my symptoms were gone. Libido was great, erections were great, energy was great, sleep was good, mood was good, I was superman. But since then, I noticed a gradual decline in some of the benefits, still being better than before, especially energy and mood, but libido comes and goes at times. So, what I am wondering, is do I need rechecked for T levels? is it likely my levels are fluctuating and that is giving me inconsistent symptom control? Is it just taking my body time to adjust to the new T level? I throw myself at the mercy of the court!
 
Libido comes and goes even with optimized TRT/Thyroid.

I would rerun lab tests. Something like this:


plus


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hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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