SelectMDX Prostate Cancer Screening Rather Than Biopsy

CoastWatcher

Moderator
A “puzzling” velocity rise in my PSA over the last 15 months prompted my urologist to utter the word, “biopsy.” I responded, “SelectMDX,” the reasonably new, non-invasive urine test that tracks two bio-markers and can rule out prostrate cancer with an extremely high degree of certainty. We decided to repeat the PSA and cross the next bridge in light of those results. Actually, that’s partially true. We will repeat the PSA, but I’m not going to have a biopsy at this point. If I meet with any resistance in obtaining the SelectMDX, I visit a different urologist.

There has been some discussion of the SelectMDX test here on the Forum, but it has only arrived in Canada recently.
 
Exactly what I just did. PSA suspicious for 1.5 years, most recently 9.3, selectMDX negative for cancer, no biopsy needed
I’m 61, and saw my PSA double in 15 months. Still below the magic number, 4.0, but the upward rise startled my urologist. I’ve dealt with LUTS off and on, so - in all honesty - I didn’t see a need to blow whistles and fire rockets.

I certainly understand the negatives associated with prostate biopsies, and the hall of mirrors that prostate screening has become. At this point, needles, guided or blind, make no sense.
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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