Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

Seagal

Well-Known Member

"The enzymatic efficiency of the conversion of DHT to androstanediol increased 163-fold when the enzyme was incubated with fluoxetine and 63-fold with paroxetine but did not change substantially with imipramine. "

Couldn't find follow-up research. Other SSRIs might have the same effect.
I assume that TRT and even DHT cream would not yield more mental drive besides the honeymoon phase.
 
Proviron, Masteron, Oxandrolone is not (significantly) converted by 3α-HSD.

Tren is converted by 3α-HSD into the more potent Tren-3α-ol.

3α-HSD: 3α-Hydroxysteroid Dehydrogenase

If SSRIs on TRT are still needed and one doesn't notice any of the supposed mental benefits of TRT, I would suggest adding proviron.
 
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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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