Scrotal Cream absorption in relation to dosage applied - seems high

[Computer_Jockey]

I think I am missing something in relation to the scrotal cream application protocols.

The scrotal application is recommended as it is 8x more effective than other transdermal applications. Numbers have been posted stating 75-85% absorption with scrotal applications.

A common protocol with scrotal applications is 100mg applied twice a day. To my mind, this means you are absorbing 150-170mg per day. That is a major dose if so.

What am I missing?

 

[Cataceous]

The figures I've seen are 10% for regular skin and 10-60% for scrotal skin.

 

[CoastWatcher]

The figures I've seen are 10% for regular skin and 10-60% for scrotal skin.

Anecdotally, my doctor remarked that in her practice she sees scrotal absorption averaging between 40-50%.

 

[Computer_Jockey]

Maybe I'm comparing apples and oranges. With the scrotal cream protocol, and assuming 40% absorption, you are introducing 80mg a day, and 560mg a week. That is over 2.5x the max dosage I usually see with injection totals (200mg). This is why I feel I must be missing some key point.

 

[Cataceous]

Anecdotally, my doctor remarked that in her practice she sees scrotal absorption averaging between 40-50%.

How does she determine absorption efficiency?

 

[Cataceous]

Maybe I'm comparing apples and oranges. With the scrotal cream protocol, and assuming 40% absorption, you are introducing 80mg a day, and 560mg a week. That is over 2.5x the max dosage I usually see with injection totals (200mg). This is why I feel I must be missing some key point.

It may be a case of diminishing returns; huge doses like that reduce the efficiency of the limited skin area. This paper found about an "eightfold increase in testosterone bioavailability, using the scrotal compared with abdominal skin routes." But the comparison was made with 12.5 mg applied to the scrotal skin. Other doses tested were 25 mg and 50 mg. The dose-response curves demonstrate the decreasing returns, with the response at 50 mg mostly less than double the response at 12.5 mg.

 

[Cataceous]

 

[CoastWatcher]

How does she determine absorption efficiency?

She said it was back-of-the-envelope, but promised to give me her notes as she’s regularly provided material for the Forum over the past four years. I need to remind her,

 

[tj]

Exactly my question! The lifting Dermatologist is promoting a cream in Europe with 150mg/g. twice a day. I dont know if you put on a gram but that would be 300 mg.
with an absorbtionrate of 10 to 50% scrotal that would mean a lot of pure test per day.
No wonder they are feeling so good

 

[pema]

I'm not well educated on this, but to mimic 200m injections daily don't you click 2 x at 6am and 2 x at 6pm (50m per click)?

 

[Computer_Jockey]

It may be a case of diminishing returns; huge doses like that reduce the efficiency of the limited skin area. This paper found about an "eightfold increase in testosterone bioavailability, using the scrotal compared with abdominal skin routes." But the comparison was made with 12.5 mg applied to the scrotal skin. Other doses tested were 25 mg and 50 mg. The dose-response curves demonstrate the decreasing returns, with the response at 50 mg mostly less than double the response at 12.5 mg.

OK, this is starting to make sense. So, with scrotal application, doubling the dose does not double the blood serum levels. Like you say, diminishing returns. Thanks for the link to the study. It and your description helped tremendously.