SARMs Control Act of 2018

Earlier this week, Senators Orrin Hatch (R-UT) and Sheldon Whitehouse (D-RI) introduced the SARMs Control Act of 2018. If passed and signed by the President, the Act would amend the Controlled Substances Act to list SARMs as Schedule III controlled substances, meaning they would be regulated by the DEA the same as anabolic steroids.

The Act defines "SARM" as "any drug or other substance that is a selective androgen receptor agonist chemically unrelated to tesosterone, estrogens, progestins, corticosteroids, and dehydroepiandrosterone . . ." Specifically scheduled (but not an exclusive list if the substance otherwise fits the definitions) are ostarine, LGD-4033 (ligandrol), RAD-140, andarine, and several other common SARMs products.

I do not see MK-677 (ibutamoren/nutrobal) listed, and while it isn't techinically a SARM, it is often sold by the same "research chem" places that sell LGD and the like. I wonder whether MK could fit under the Act's catchall definition SARMs not otherwised listed, which states that a substance shall be considered a SARM if it:

  • (I) has been created or manufactured with the intent of producing a drug or other substance that—

  • (aa) promotes muscle growth; or

  • (bb) otherwise causes a pharmacological effect similar to that of testosterone;


or (II) has been, or is intended to be, marketed or otherwise promoted in any manner suggesting that consuming the drug or other substance will promote muscle growth or any other pharmacological effect similar to that of testosterone.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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