Rewriting Aging: Dr. Mark Tarnopolsky on Mitochondria, Muscle & Longevity

madman

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In this episode of The DNA of Things, Dr. Jeremy Koenig sits down with legendary physician-scientist Dr. Mark Tarnopolsky to explore how exercise, nutrition, and genetics intersect to reshape the aging process. With over 500 peer-reviewed publications and decades of research in neurometabolic disorders, Dr. Tarnopolsky reveals groundbreaking insights into mitochondrial health, protein optimization, gene-environment interplay, and the future of therapeutics for aging and rare diseases.

This episode is a must-listen for anyone interested in the science of longevity, athletic performance, or functional health optimization.





Key Takeaways:

* Aging is not a sentence:
Discover how cellular function can be reshaped through lifestyle.

* Muscle as medicine: Resistance and endurance training are critical for aging well and combating neuromuscular disorders.

* Protein timing & quality matter: Why whey, casein, and leucine-rich sources outperform trendy supplements.

* Exercise mimetics: Learn about Dr. Tarnopolsky’s breakthrough supplements like Muscle5 and Trim7 that simulate the metabolic effects of exercise.

* From elite athletes to mitochondrial patients: How training principles apply across the human performance spectrum.

* Clinical-grade nutraceuticals: Why randomized, double-blind studies must back health claims—and how his startup is setting the gold standard.

* Genetics vs. epigenetics: Why knowing your genome is just the start—methylation, glycosylation, and environment matter too.

* The future of healthspan: How brown fat, mitochondrial biogenesis, and smart protein dosing are changing the longevity game.
 
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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