Review: Novel Mechanisms of DHEA Action

DHEA to me I take the same position on it as Anastrzole, should never be a basic inclusion in some one's protocol and not even based on testing, it should be used with caution. As my friend CW posted it can be wrought with E problems for some guys no matter what form or how it's taken. Often dosed too high, too 2 25-50mg. Anyone using DHEA should consider a low 5-10mg dose that tirates upward based on tolerance. Just because a test reads "low" doesn't mean you need it or should take it.
 
For me I only use DHEA, to keep my levels of in the normal range. Making sure they're not too high. I supplement with 25 mg every morning after breakfast. Using it before bedtime keeps me awake.
 
I always thought it was somehow suppressive to my system, but lately I have been experimenting and benefitting with higher dosages and post-workout earlier in the day, timing. I am using 100mg and it seems to be helping my lifting and afternoon energy. I take it right after lunch following my workouts.
 
DHEA to me I take the same position on it as Anastrzole, should never be a basic inclusion in some one's protocol and not even based on testing, it should be used with caution. As my friend CW posted it can be wrought with E problems for some guys no matter what form or how it's taken. Often dosed too high, too 2 25-50mg. Anyone using DHEA should consider a low 5-10mg dose that tirates upward based on tolerance. Just because a test reads "low" doesn't mean you need it or should take it.

I was excited to add it to my protocol a while, a good while, ago and my doctor asked me to explain why it was necessary. My levels were normal, I'd brought my E2 into line without an AI and I felt great. When she put it that way, and after digging in and seeing some of the problems guys here report with it, I realized it wasn't in my future.
 
I was excited to add it to my protocol a while, a good while, ago and my doctor asked me to explain why it was necessary. My levels were normal, I'd brought my E2 into line without an AI and I felt great. When she put it that way, and after digging in and seeing some of the problems guys here report with it, I realized it wasn't in my future.

I would have to agree with you, it's not something everyone should supplement with.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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