Renal Protection of Metformin

madman

Super Moderator

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in The Journal of Clinical Endocrinology & Metabolism providing data in support of metformin being renal protective. He talks with Steven D. Wittlin, MD, from the University of Rochester Medical Center and guest expert Silvio Inzucchi, MD, medical director of the Yale Medicine Diabetes Center. The article featured this month, by Wang et al, was first published online in JCEM in July 2024: “Renal Protective Effect of Metformin in Type 2 Diabetes Patients.”
 

Table 1. Metformin management in patients with T2DM with stage 3A, 3B, and 4 CKD.​



CKD stage



eGFR (mL·min-1·1.73 m-2)



Recommended daily dose



3A​



45-59​



0.5 g in the morning + 1 g in the evening​



3B​



30-44​



0.5 g in the morning + 0.5 g in the evening​



4​



15-29​



500 mg in the morning​

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A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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