Relation of Testosterone, Dihydrotestosterone, and Estradiol With Changes in Outcomes Measures in the Testosterone Trials - PMC
Many effects of testosterone are mediated through dihydrotestosterone (DHT) and estradiol. To determine the relative contributions of each hormone to the observed effects of testosterone treatment in older men with hypogonadism. Using data from the ...
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"These analyses were not prespecified and need confirmation in additional studies of other datasets. Our models were modestly predictive, with r-squared values ranging from 0.16 for HDL cholesterol to 0.27 for vBMD, indicating that there is substantial variation in the testosterone response that is not explained by changes in these 3 hormones."
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