Recently transitioned from compounded cream → injectable TRT.

mcs

Member
65 y/o | 165 lbs | 5’6” | ~10–12% BF

Recently transitioned from compounded cream → injectable TRT.
  • Reason: DHT spiking and unstable serum levels.
  • Current protocol: Test E in MCT oil, 11 units ED (~21 mg), ~150 mg/week total, subq/IM microdosing. Plan: 6 weeks → labs → add Deca 50 mg/week for joint relief/inflammation.
Androgen-related labs comparison:

June 2025 (on cream, peak; applied 2h prior ):

  • TT: 1034 ng/dL
  • Free T: 191.6 pg/mL (H)
  • SHBG: 52
  • DHT: 144 ng/dL (H)
  • Estradiol: 46 pg/mL (H)
  • LH: 2.4 / FSH: 4.2
  • Prolactin: n/a

Sept 2025 (cream → pre-injectable):
  • TT: 318–459 ng/dL (applied 12h prior)
  • Free T: 61.5–70.7 pg/mL (↓)
  • SHBG: 36–39
  • DHT: 122–145 ng/dL (still high)
  • Free DHT: 9.32 pg/mL (H)
  • Estradiol (ultrasensitive): 24 pg/mL (normalized)
  • LH: 0.6–0.8 (L) / FSH: 1.0 (L) → HPTA suppressed
  • Prolactin: 6.7–6.9 ng/mL
Observations:
  • On cream: supraphysiological TT/FT + elevated E2 + high DHT.
  • By Sept: TT/FT crashed, gonadotropins suppressed, E2 normalized, but DHT stayed elevated.
  • Prolactin baseline looks safe to trial low-dose nandrolone.
Questions for the group:
  • Experiences pivoting from transdermal to daily microdosed injections (stability, labs, symptom changes)?
  • Anyone add low-dose Deca (50–100 mg/week) for joints — what benefits/downsides did you see?
  • Best strategies you’ve used to keep DHT in check post-cream transition?


 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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