Raise Testosterone, Preserve Fertility: Enclomiphene vs Clomiphene vs TRT

[madman]

Enclomiphene can boost testosterone while preserving fertility. Board-certified urologist Dr. Justin Houman explains enclomiphene vs clomiphene and TRT, dosing, results (150–200 point T rise), side effects, labs, and who should use it. If you’re a younger guy with low T who still wants kids, this is for you.




Chapters

0:00 Low T + Fertility: The Real Problem
0:20 The Solution in One Line: Why Enclomiphene (not TRT)
1:00 How It Works: LH/FSH & the HPT Axis Reset
1:45 Enclomiphene vs Clomiphene/Zuclomiphene (Gas vs Brakes)
2:30 What You Can Expect: Benefits & Results
3:05 How to Take It: Simple Dosing Basics
3:35 Safety Snapshot: Side Effects & Estrogen Stability
4:05 What to Monitor: Labs & Follow-Up
4:35 Access & Practicalities: Compounding + Who It’s For
5:10 Lifestyle Stack: Training, Diet, Sleep
6:00 Timeline: When You’ll Feel a Difference
6:40 Final Advice & Next Steps (Watch This Next)

 

[madman]

Thread 'ENCLOMIPHENE VS. CLOMIPHENE: SAFETY AND TESTOSTERONE LEVELS IN HYPOGONADAL MEN'

Apr 19, 2024

INTRODUCTION AND OBJECTIVE

Both clomiphene citrate and its isomer, enclomiphene, have become increasingly widespread within urologic practice; thus, understanding these medications' comparative benefits and risks is crucial for optimizing treatment decisions and providing improved therapeutic options. We sought to investigate the benefits and risks associated with enclomiphene, compared to clomiphene.

METHODS

We retrospectively reviewed patients at our center from 01/01/2021-12/21/2022. All included patients were prescribed clomiphene before...

• madman
• hypogonadism; clomid/enclomiphene; adverse events
• Replies: 3
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

Thread 'Safety and Efficacy of Enclomiphene Compared to Clomiphene in Men with Low Testosterone'

Feb 17, 2024

*Our findings show that enclomiphene provides the same magnitude of improvement in testosterone but through safer means, as noted by its lower rate of documented adverse events

*Further research and larger studies are warranted to validate these conclusions and explore additional long-term effects of enclomiphene

(094) Safety and Efficacy of Enclomiphene Compared to Clomiphene for Hypogonadal Men

AbstractIntroduction. Clomiphene, and its trans isomer enclomiphene, have been used off-label in recent years for hypogonadal men seeking to maintain ferti

academic.oup.com

Abstract

Introduction

Clomiphene, and its trans isomer enclomiphene, have been used off-label in recent years for hypogonadal men seeking to maintain fertility. Both...

• madman
• clomid/enclomiphene; tth; safety
• Replies: 7
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

• 

Thread 'ENCLOMIPHENE IS ASSOCIATED WITH HIGHER PREGNANCY RATES WHEN COMPARED TO CLOMIPHENE IN INFERTILE MEN WITH LOW T'

Mar 25, 2023

MP43-13 ENCLOMIPHENE IS ASSOCIATED WITH HIGHER PREGNANCY RATES WHEN COMPARED TO CLOMIPHENE IN INFERTILE MEN WITH LOW TESTOSTERONE (2023)
Jordan Kassab, Juan Torres-Anguiano*, John Lindsey, Houston, TX; Jabez Gondokusumo, Sabine Itani, Mohamad Jabin, Bryan, TX; Larry Lipshultz, Houston, TX


INTRODUCTION AND OBJECTIVE

Clomiphene citrate has been used for decades for female infertility; however, it has also been used off-label for many years to treat infertile males with low testosterone. Enclomiphene citrate is the trans isomer of clomiphene citrate and is another...

• madman
• enclomiphene; fertility; pregnancy; serm
• Replies: 1
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

• 

Thread 'Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of RCTs'

Oct 10, 2025

Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials - Archives of Endocrinology and Metabolism

Abstract Objective: This study aimed to evaluate the efficacy and safety of selective estrogen receptor modulators (SERMs), specifically clomiphene and enclomiphene, in treating men with functional hypogonadism. Materials and methods: A systematic search was conducted in PubMed, Embase, the...

www.aem-sbem.com

ABSTRACT

Objective

This study aimed to evaluate the efficacy and safety of selective estrogen receptor modulators (SERMs), specifically clomiphene and enclomiphene, in treating men with functional hypogonadism.


Materials and methods

A systematic search was conducted in PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov for randomized controlled trials comparing SERMs...

• madman
• clomid; serm; male infertility; testosterone fertility
• Replies: 1
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

Thread 'Clomiphene citrate: A potential alternative for TRT in men with low testosterone'

Mar 31, 2023

Clomiphene citrate: A potential alternative for testosterone therapy in hypogonadal males (2023)
M. Huijben | M. T. W. T. Lock | V. F. de Kemp | J. J. H. Beck | L. M. O. De Kort | H. M. K. van Breda


Abstract

Background

Hypogonadism is a worldwide problem among men causing sexual, physical, and mental problems. Testosterone therapy is the first-choice treatment for male hypogonadism, with several side effects, that is, subfertility. Clomiphene citrate (CC) is an alternative off-label therapy for a certain group of hypogonadal males, especially for those with an...

• madman
• clomid; hypogonadism; fertility; serms
• Replies: 19
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

• 

Thread 'Fertility-Focused Testosterone Therapy: Comparing hCG, Clomiphene, and TRT Strategies for Men'

Aug 20, 2025

* Use of hCG+TRT suppressed LH and FSH (p<0.05), whereas CC+TRT was associated with reduction in FSH only (p=0.02). However, at 6 months, CC monotherapy was associated with significant increases in LH and FSH (p<0.001). As expected, all three treatments were associated with substantial increases in both total and free testosterone within 6 months with rapid attainment of physiological levels (ranging from 23.58nmol/L to 26.52nmol/L). Similar magnitudes of increases in QADAM scores were observed across the three approaches (from 7.86 points to 9.50 points, all...

• madman
• hypogonadism; t-therapy; clomid; hcg; fertility
• Replies: 5
• Forum: Testosterone and Men's Health Articles

Post in thread 'Testosterone & Fertility: Novel Techniques in Monitoring & Treating Hypogonadal Fertile Men: SERMs, hCG, rFSH, Aromatase Inhibitors'

Oct 18, 2025

Benefits

* Preserve fertility

* Increase natural T




Enclomiphene Citrate (EC)

Application

Dosing

Side effects/Disadvantages

Benefits

Enclomiphene Efficacy

Enclomiphene Data

Randomized Phase II trial

Enclomiphene vs. Clomiphene

• madman

Thread 'Fertility maintenance or restoration in men before, during, and after TRT or AAS'

Sep 25, 2022

Fertility Preservation in Hypogonadal Men (2018)
Robert J. Carrasquillo and Ranjith Ramasamy


Introduction

Testicular failure is defined as the impairment or loss of both the endocrine functions of the testis (production of testosterone, or T) and exocrine function (production of spermatozoa). Testicular failure can result from the pathology of the testis itself or disorder at any point in the hypothalamic-pituitary-gonadal axis. Primary testicular failure is characterized by normal/low T in the presence of the elevated follicle-stimulating hormone...

• madman
• fertility/spermatogenesis; tth/aas; hypogonadism
• Replies: 32
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

• 

 

[DaveK2204]

Enclomiphene can boost testosterone while preserving fertility. Board-certified urologist Dr. Justin Houman explains enclomiphene vs clomiphene and TRT, dosing, results (150–200 point T rise), side effects, labs, and who should use it. If you’re a younger guy with low T who still wants kids, this is for you.




Chapters

0:00 Low T + Fertility: The Real Problem
0:20 The Solution in One Line: Why Enclomiphene (not TRT)
1:00 How It Works: LH/FSH & the HPT Axis Reset
1:45 Enclomiphene vs Clomiphene/Zuclomiphene (Gas vs Brakes)
2:30 What You Can Expect: Benefits & Results
3:05 How to Take It: Simple Dosing Basics
3:35 Safety Snapshot: Side Effects & Estrogen Stability
4:05 What to Monitor: Labs & Follow-Up
4:35 Access & Practicalities: Compounding + Who It’s For
5:10 Lifestyle Stack: Training, Diet, Sleep
6:00 Timeline: When You’ll Feel a Difference
6:40 Final Advice & Next Steps (Watch This Next)

I would like to hear more about users experience with the EOD protocol. I believe Enclompihene has a half life of ~10 hrs vs Clomid is ~5 days. Seems like daily would be better for Enc. but maybe the receptors like more of a variable state?