Questions about T/E2 ratio.

jobshopper

Active Member
It seems that there is a lot of emphasis on T/E2 ratio.

Why do you suppose that labs like Quest, LabCorp, etc. don't report E2 results as a T/E2 ratio if that is what is more important than just the E2 results?

And, why do you suppose they don't adjust the "range" to take into consideration the "projected range" of E2 as tabulated by @Nelson?

And one more question, should men who have a high T/E2 ratio based on a low E2 level be taking Estradiol to bring their E2 levels up to improve their T/E2 ratio? If not, then why not?

Thoughts?
 
As far as the first aspect, most doctors are behind the best minds here on this site, as well as the best minds on other T forums. For instance, my doctor (a urologist) thinks the lower the estradiol, the better off you are. (And I once texted him about "E2", and he didn't know that was estradiol.) If the doctors are behind the curve, it makes sense that the labs are too. Just look at some of their ranges.

That said, I'm a very lucky man to have the doctor I have. Though he is not up-to-speed on trt, he is very liberal in prescribing and very amenable to my requests. Just think of all those 100mg e2w doctors out there - scary stuff and further proof of the medical community at large not being in the loop.
 
As far as the first aspect, most doctors are behind the best minds here on this site, as well as the best minds on other T forums. For instance, my doctor (a urologist) thinks the lower the estradiol, the better off you are. (And I once texted him about "E2", and he didn't know that was estradiol.) If the doctors are behind the curve, it makes sense that the labs are too. Just look at some of their ranges.

That said, I'm a very lucky man to have the doctor I have. Though he is not up-to-speed on trt, he is very liberal in prescribing and very amenable to my requests. Just think of all those 100mg e2w doctors out there - scary stuff and further proof of the medical community at large not being in the loop.
Thanks for your input.

As for my 3rd question, do you have any input on that?
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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