Questions about hypothyroidism

themedulla

New Member
I'm a 52yo male 6'3" 215 lbs. I have thyroid panels running back to 2009. Since that time I have been testing mostly with TSH in the 3-4.5 range. I might have a blip where I test with 2.5. My primary care insists they are all in the normal range so he is not inclined to treat. My energy levels are generally pretty poor. They are better now that I have been diagnosed with sleep apnea and use a CPAP machine, but still not great.

I am dealing with symptoms that seem to be a better fit for TRT, but I'm curious about getting thyroid treatment. One of my questions has to do with trying replacement therapy. I guess I don't understand if this is something you can try, or once you start taking thyroid medications you shut down your natural production (permanently?).

Other than the lack of energy, I can't make gains in the gym. Even 10 years ago I could make gains pretty easily if I was consistent at the gym and took in enough protein. My libido has completely disappeared. Irritability? Check.

I just got some labs done from a TRT clinic. For whatever reason they did not order a free testosterone lab, only a total. I'm not even sure what the value of a total testosterone lab result is given that it is the free test that matters and the two aren't necessarily correlated. Anyway, my total test is actually pretty reasonable for a 52yo (750 total). Some of the other numbers make me wonder if I don't have something else going on so I'm again wondering if I should seek treatment for what is at the very least suboptimal thyroid function (and maybe clinical). What are the pros and cons of giving it a shot?
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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