[Question] Frequent Urination + Hypogonadism (crashed E2)

[Checkdis]

Hello, to give a little info about myself, I am currently 6'1 at 200lb, 28y/o. I had blood work done back in the beginning of March and my levels were 2120.8 Test, and >50 Free test. ALT was 47 and creatine was a bit high but nothing uncommon. I ran 2 cycles back to back, with no breaks, which I am now regretting. Here was the layout:


Cycle:

Week 1-6: 1ml (250mg) Gonadon Sust. 1 pin a week, Stacked with 50mg of Iranian anadrol ED (first 6 weeks)
Week 7-12: 2ml (500mg) Gonadon Sust. 1 pin a week


Week 12-15: 1ml (250mg) Test E & .5ml Tri-tren , pin twice a week
Week 15-25: 1ml (250mg) Test E & 1ml Tri-Tren, pin twice a week

Ran Pharmagrade hcg the whole 6 months stacked above, 500iu once weekly.

pct:

clomid/nolvadex/adex - 50/20/1mg ED Week 1
Clomid/Nolvadex/Adex - 25/20/.5mg ED Week 2
nolva - 10mg ED Week 3,4

Diagnoses:
Anxiety/Panic
Hypogonadism
OAB (Overactive Bladder)

I have no blood in the urine, no pain, no discomfort, no back pain, prostate is normal PSA 0.3 and other ranges normal, Pituitary normal (ACTH, no head aches, no vision impairment). I do sweat very easily under any temperature with little to no activity. I Also have hemorrhoids, which I am addressing soon.

Prescription Medication:
Lexapro 10mg ED
clomiphene Citrate Tablet 25mg ED
VesiCare 5mg ED

Lab results:
Low Total testosterone
Low Bioavailability Testosterone
Low Dihydrotestosterone (DHT)
Low Estradiol (E2)
Low FSH
Low LH
Low Vitamin D

Tests:
Colonoscopy - Found 1 Polyp, benign. Pathology report was clean
Abdominal ultrasound - Everything looked normal, smooth liver no inflammation.

Supplements:
Vitamin D3 10,000iu - once everyday with meal in the morning

Ruled out:
Diabetes Insipidus
Diabetes
UTI
BPH
Prostate
Epididymis
Pituitary
Hepatitis
STD (All)
No infections

(Cannot really rule out Kidneys and Liver 100% since no CT, MRI, X-ray was conducted, labs show organs as normal, and Abdominal ultrasound showed no enlargement)

Currently my doctor is allowing me to run a course of Clomid as a form of mono-therapy for TRT. I will be cycling only Clomid for 3 months, and lab work done every 3 weeks. My main concern is my frequent urination. To get an idea, I was 235lb back in April, I now weigh 196-200lb, yeah it sucks... Sometimes I am dehydrated by the amount I urinate. I have no difficulties urinating, and only get up once to go at night. I am attaching my labs below (all personal information has been redact in PDF), I greatly appreciate any feedback and I also had some questions.


Can Low T/low E2 cause frequent urination, if yes, do you have a article/research about it?

How long does the body take to stabilize naturally coming off Testosterone?

Also I have heard crashed estrogen can cause my symptoms, is this true? And can estrogen be permantly crashed?



Is there anything I can do besides Kegels to improve OAB?

 

[Nelson Vergel]

Try to avoid these foods and see if that makes a difference. I just learned that some of these were making me go to urinate more frequently due to bladder irritation. Has the VesiCare helped?

View attachment 4126

Your PCT did not seem to work if the last blood test #4 is after PCT. What clomiphene dose are you taking now? Did you use hCG before PCT?

 

[Checkdis]

Try to avoid these foods and see if that makes a difference. I just learned that some of these were making me go to urinate more frequently due to bladder irritation. Has the VesiCare helped?

View attachment 4126


Your PCT did not seem to work if the last blood test #4 is after PCT. What clomiphene dose are you taking now? Did you use hCG before PCT?

I wasn't able to cut milk from my diet, but everything else checks out. My diet pretty much consists of cereal in the morning with milk, yogurt for lunch with granola, and dinner is pasta with chicken or other types of protiens. Thank you for the photo.

Yes I am pretty sure my PCT failed. And from what I heard, Tren really shuts down your system.

I am currently taking 25mg of Clomid everyday until told otherwise. And yes I did take hcg before my PCT but I am starting to think it wasn't real. I bought a pregnancy test and pour a whole vial on the node and came up negative so my assumption was the HCG is fake (guess I'm not pregnant).

I also learned that Arimadex shouldn't be taken during PCT which I mistakenly did. This caused my estrogen to crash hard. I am pretty much at rock bottom with my hormones.

 

[JPB]

If I read your post correctly, your PCT was too short and not long enough, with your follow-up labs in too close proximity to your cycle. I would not expect a rebound quite that soon. So it seems it just needs more time. Also low T can cause symptoms of BPH. The prostate likes adequate saturation of T or it starts to develop symptoms. Daily cialis helps and getting T levels back in a healthy range.

 

[Saul]

I can share my experience. Short background - per doctor, too much iron in my body caused low T. I would usually get up in the night to pee and in the morning/when I had to go, I had to go right away - no incontenance, but just low ability to hold it in or a strong feeling to gotta pee now. Sucked.

The high iron was a health scare for me so I cut out dairy, most acidic juices, cut way back on the booze (I was a beer with dinner guy), cut way back on sugar, reduced iron, and am on test cyp. All those symptoms are gone. I don't get up in the night, even after having liquids before bed, and when I get up, it is not a rush to go pee, - I am able to get dressed and go down stairs, then take a leak. Still have to go, but just have some time after getting up.

I hope this is helpful. I feel for ya cause it is a pain having to go asap. Maybe you can get back on track. Good luck.

 

[Checkdis]

Thank you for the feedback guys. It is reassuring I will eventually get better. It has just been 5-6 months with this bs and the urination created anxiety and concern for my health. Also was afraid of dehydration and other things. On top of it my PCP gave me Augmentin for a blood work that had high white blood count which killed my gut, felt like spicy Mexican food coming out. So now I shit like 3 times in the morning from 5:30 to 8am. Lost all my gains and to be honest never really want to touch this stuff again sadly. I love lifting and learned a lot from it.

I just want to get off this Lexapro and Vesicare. The Clomid is working nicely for me, I just hope I didn't burn out my balls.

 

[Vitamin_C]

I don't see your E2 labs, am I blind?

 

[Vince]

I don't see your E2 labs, am I blind?

It's on the last lab, the wrong estradiol test <5. As we know it should be the estradiol sensitive test for men.

Why All Men Should be Tested with the Sensitive Estradiol Test

https://www.excelmale.com/forum/sho...d-be-Tested-with-the-Sensitive-Estradiol-Test

 

[Checkdis]

If my standard E2 is <5 I would think either test would be sufficient right?

What is the code that LabCorp needs for E2 sensitive? My doctor wrote estrogen on the script but nothing stating sensitive. I can attempt to specificy when I go in for my monthly blood work maybe.

Does really low estrogen cause frequent urination?? Why is that?

 

[Nelson Vergel]

"Antihistamines such as hydroxyzine (Atarax, Vistaril) interfere with the mast cells' release of histamine, helping to relieve bladder inflammation and pain, urinary frequency, and nighttime voiding. Because antihistamines can cause drowsiness, they are usually best taken at bedtime."

https://www.health.harvard.edu/diseases-and-conditions/treating-interstitial-cystitis


Also

FDA approves first treatment for frequent urination at night due to overproduction of urine

 

[CoastWatcher]

If my standard E2 is <5 I would think either test would be sufficient right?

What is the code that LabCorp needs for E2 sensitive? My doctor wrote estrogen on the script but nothing stating sensitive. I can attempt to specificy when I go in for my monthly blood work maybe.

Does really low estrogen cause frequent urination?? Why is that?

LabCorp test number 140244.

https://www.labcorp.com/test-menu/24871/estradiol-sensitive-lc-ms

 

[Checkdis]

UPDATE:

I feel a lot better taking Clomiphene Citrate 25mg everyday. Seems my crashed estrogen caused me to urinate a lot. I guess my estrogen was so low.

Thanks for the info, I just had blood work done on the 4th and I should get the results in next week.

 

[Checkdis]

Update:

So far I have been taking 25mg everyday of Clomiphene Citrate for just about 2 months. I have stopped lexapro (tapered off), VesiCare, Amitriptyline, and Ativan successfully without any complications, i'm very happy for myself and impressed. I currently take 10,000iu of Vitamin D3 everyday with an occasional DHEA 100mg. No multivitamins, no supplements, just a clean diet. BP is 120/80 which is great. Temperature 98.6

Here are my recent labs if anyone wants to take a look. So far I have improved a lot and my urination from what it was before slowed down drastically. I will have days once and a while where I'll go to the bathroom 6-8 times. But that is better than 20.

Mood wise I am alright (scale of 1-10 I would say 7ish), some days I fear like something is really wrong with me which happens for a minute, so I take a deep breath and try and relax.

Who would have ever known estrogen can cause so much chaos.

i do have a concern about my glucose, the last few months it's has been hovering around 94. But urine hasn't shown any glucose.

 

[CoastWatcher]

Update:

So far I have been taking 25mg everyday of Clomiphene Citrate for just about 2 months. I have stopped lexapro (tapered off), VesiCare, Amitriptyline, and Ativan successfully without any complications, i'm very happy for myself and impressed. I currently take 10,000iu of Vitamin D3 everyday with an occasional DHEA 100mg. No multivitamins, no supplements, just a clean diet. BP is 120/80 which is great. Temperature 98.6

Here are my recent labs if anyone wants to take a look. So far I have improved a lot and my urination from what it was before slowed down drastically. I will have days once and a while where I'll go to the bathroom 6-8 times. But that is better than 20.

Mood wise I am alright (scale of 1-10 I would say 7ish), some days I fear like something is really wrong with me which happens for a minute, so I take a deep breath and try and relax.

Who would have ever known estrogen can cause so much chaos.

Thank you for the update. Congratulations on your improving health.

 

[Checkdis]

Well it seems i’m back to were I was, having the urge to urinate but with my levels getting better. I have ran out of ideas on what is going on?

 

[FeelingLost]

Well it seems i’m back to were I was, having the urge to urinate but with my levels getting better. I have ran out of ideas on what is going on?

Are you completely off the SSRI's now?
I took Lexapro for about a month and it really screwed my bladder/prostate up. Not to mention libido. IMO SSRI's should be a last resort.
My PCP switched me to Buspar and it worked wonders. Took about 6 weeks off the lexapro to recover.
hth

 

[Checkdis]

Are you completely off the SSRI's now?
I took Lexapro for about a month and it really screwed my bladder/prostate up. Not to mention libido. IMO SSRI's should be a last resort.
My PCP switched me to Buspar and it worked wonders. Took about 6 weeks off the lexapro to recover.
hth

Yeah it could be that. I’m starting to think my urination is a result of anxiety. But from what I have been hearing, I will just have to be patient.

The strange thing is some days are better than others. I feel really scared like something bad is going to happen to me, then it goes away. And my symptoms seem to vanish in the afternoon around 2-4pm

 

[FeelingLost]

Yeah it could be that. I'm starting to think my urination is a result of anxiety. But from what I have been hearing, I will just have to be patient.

The strange thing is some days are better than others. I feel really scared like something bad is going to happen to me, then it goes away. And my symptoms seem to vanish in the afternoon around 2-4pm

I've been there my friend and it can get worse. When you have an episode try to think back on what you've been saying to yourself (selftalk) negative selftalk if taken too far can really hurt you. Everytime you catch yourself thinking negative or getting mad and thinking about it over and over force yourself to stop.

The issues I have with SSRI's is they hurt you(loss of libido, ED, lose of the ability to climax) for the rest of your life even after you stop taking them.
Do some research on the side effects of Lexapro and SSRI's in general. Ask your doctor if there is something else, with less side effects, you can try.

 

[Checkdis]

I've been there my friend and it can get worse. When you have an episode try to think back on what you've been saying to yourself (selftalk) negative selftalk if taken too far can really hurt you. Everytime you catch yourself thinking negative or getting mad and thinking about it over and over force yourself to stop.

The issues I have with SSRI's is they hurt you(loss of libido, ED, lose of the ability to climax) for the rest of your life even after you stop taking them.
Do some research on the side effects of Lexapro and SSRI's in general. Ask your doctor if there is something else, with less side effects, you can try.

I agree with you there SSRI’s are a terrible drug, for children and adults. Luckily I do not take Lexapro anymore. But I do take Amitriptyline to help me sleep, and one of the sides is it prevents you from urinating so it helps I guess.

Ativan surprisingly cures me but I do not want to be addicted to a benzo. The withdrawal from that drug can be a lot worse than what I am going through. Also long showers and baths help lol.

It is like I have lost that cognitive ability to control my thoughts. Never had suicidal thoughts ever. But when I start thinking, I go into this trance state where I cannot be happy anymore if that makes sense. Seems stress and anxiety run my life now. I don’t mind stress, it keeps me focused, but this damn anxiety with brain fog and urination kills me. I cannot read F’ing subtitles anymore in a movie, shit moves way too quick now.


It has been 6 months with this crap, I guess I have to keep waiting and be patient.

 

[FeelingLost]

As a retired engineer I go into troubleshoot mode when my body starts acting up. I'm a data gathering fool,
my PCP hates it because I make him prove everything he says.
Here's my sleep pattern when my night time toilet visits was at its worst the pink lines means I got up to pee.
Light blue light sleep, dark blue deep sleep.



After 6 months of TRT, finding the right supplements, cleaning up my diet, starting daily exersize, 3 months with a Therapist who specializes in EMDR to fix my selftalk I am here.



So it is possible. Hang in there and keep searching. Watch the self talk it can take your sanity from you.

hth