Protocol Review: Low E2 Symptoms w/ High E2 Bloodwork

get2dichoppa

New Member
1st Protocol:

100mg Test Cyp 2x per week (200mg Total)
.5mg AI 2x per week (1mg Total)


Labs on First Protocol (trough test):

TT = 955 (348 - 1197)
FT = 29.3 (9.3-26.5)
E2 Sensitive = 10 (8-35)


Clearly I crashed my E2. Symptoms were ED, anxiety, clicking joints, dry skin, insomnia. Also had quite a bit of hair shedding. Im a low SHBG guy so I thought more frequent injections would help, and I dropped the AI completely.


2nd Protocol:
30mg T Cyp EOD (~105mg per week total) mixed btw SubQ & IM
No AI


After 4 weeks on this protocol (trough test):


TT = 835 (348-1197)
FT = 33.82 (5-21)
E2 Sensitive = 60.3 (8-35)
HCT = 48.5


The weird thing is my symptoms are a mix of low/high E2. ED, dry skin, clicking joints, insomnia, night sweats, sweating alot during workouts, bloat. I definitely feel better with high E2 than low E2, although thats not saying much.

What do you recommend for guys with super low SHBG? Im thinking of cutting my 30mg EOD down to 20mg EOD and adding in some DIM to help my liver clear out the estrogen. Any thoughts or help, thanks guys.

EDIT: Male 6'3 210lbs (BMI = 25)
 
If it were me I'd leave the protocol as is and add AI .25mg once per week, retest in 4 and then adjust the AI based on symptoms first and labs second.
 
If it were me I'd leave the protocol as is and add AI .25mg once per week, retest in 4 and then adjust the AI based on symptoms first and labs second.

Thanks for the suggestion Vince. I will consider that, and also mention it to my doctor. The only reason I wanted to lower my dose is because my Free T is so high I feel I have room to bring that down, without introducing more drugs to my system. As far as I know, Free T is the more important measure that TT, so I dont mind if the TT drops a little
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
3
Guests online
186
Total visitors
189

Latest posts

Back
Top