Prostate Cancer Screening Blood Tests: OPKO 4K, PHI, & Free PSA

[madman]

In the video, Dr. Marshalls, a medical oncologist with 30 years of experience in prostate cancer, discusses various blood tests used for prostate cancer screening. He explains the limitations of PSA (Prostate-Specific Antigen) tests, which can indicate issues with the prostate gland but are not cancer-specific. He introduces more advanced tests like Phi, opco 4K, and free PSA, which provide greater accuracy in detecting significant prostate cancer types. These tests can help avoid unnecessary biopsies and MRIs, although their high cost and limited efficiency in certain cases may reduce their use.

Dr. Marshalls emphasizes the importance of contextualizing test results, noting that advanced tests often better identify consequential prostate cancers. He discusses real-world applications, including a case study of a 74-year-old man with an elevated PSA, using opco 4K to determine the need for further investigation.

He also addresses the accessibility and insurance coverage of these tests, suggesting that in places with limited MRI access, these advanced blood tests are valuable. Dr. Marshalls concludes by encouraging patients to understand and discuss their test results with their doctors, emphasizing the importance of mental and emotional support throughout the screening and diagnosis process. The video also promotes the upcoming prostate cancer conference and offers resources for further support.

0:37 What is PSA and what role does it play in cancer screening?
2:03 What role do blood tests play in screening prostate cancer?
6:30 In what context would a patient be advised to take a blood test?
8:00 How are blood test results usually interpreted?
10:21 Is high grade prostate cancer considered slow growing if it is caught early?
11:10 What is the difference between a tissue biopsy and a blood test?
12:31 Does insurance usually cover blood test?
12:40 What differentiates free PSA from standard PSA tests?
13:07 How long does it take to get the test results
?13:41 What should men do with a middling risk score?
15:04 Alex's conclusions

 

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[mcs]

I have a NORMAL PSA but consistently low FREE PSA. Should I be concerned?
Low percentage of free prostate-specific antigen (PSA) is a strong predictor of later detection of prostate cancer among Japanese men with serum levels of total PSA of 4.0 ng/mL or less - PubMed

 

[madman]

I have a NORMAL PSA but consistently low FREE PSA. Should I be concerned?
Low percentage of free prostate-specific antigen (PSA) is a strong predictor of later detection of prostate cancer among Japanese men with serum levels of total PSA of 4.0 ng/mL or less - PubMedView attachment 47640

0:09 What is "free PSA," how does it differ from PSA testing, and is it still relevant in 2022?


Pay close attention here 1:06-3:06

* free PSA is a subtype of PSA that is made less frequently in men with big prostates

* free PSA will help tell you which of those patients are the guys with big prostates and maybe if they have this type of free PSA which signals a big prostate maybe the elevated PSA isn't coming from cancer maybe it's coming from the big prostate

* when the % of free PSA drops below say 9% that suggest a big prostate is not present and therefore a PSA elevation is more likely to be from prostate cancer or prostatitis and maybe further investigation is necessary







1:33-3:03