Hi guys,
This is my first proper post – I am happy I found this place as it has been an interesting read for the last few days. I have gone over as many anastrozole / Adex posts/threads as I can but cannot quite find specifically what I am looking for, so I hope you do not mind me asking.
Some brief context:- I am 37 years old male, from the UK. 5’65 and 72kg (sorry for the mix of imperial / metric), in decent shape I go to the gym and eat a balanced healthy diet with a robust supplement regimen.
Edit before posting: I am going to cut my life story! Not relevant how I got here, but here I am
Prior to starting TRT, blood test no: 1 on 2nd July 2021:
Total T was 10.6 nmol/L (ref range 8.6 – 29)
Free T (FTI) 0.3 (ref range 0.2 – 0.62)
So In the gutter almost for 36 yrs old healthy male, at that time.
E2 was 80 (ref range 41 – 169) – normal I guess
2nd test on 10th August 2021:
Total T was 12 nmol/L (ref range 8.6 – 29)
Free T (FTI) was 0.2 (ref range 0.2 – 0.62)
E2 was 85 (ref range 41 – 169)
The dr concluded I had very low T and I could start TRT if I wanted.
I started TRT on the 21st August 2021
100mg of Test Cypionate, 3x PW, SubQ.
HCG 1050iu 3x PW (350iu per shot), SubQ, administered at the same time as the Test C.
After almost 6 weeks on this protocol I had a blood draw, and the results came back as follows
Total T at 36.6 (ref range 8.6 – 29).
Free T at 1.0 (ref range 0.2 – 0.62)
E2 at 235 (ref range 41 – 169)
Following the consultation, the Dr was not so concerned about my T being higher at the present moment, but was concerned my E2 was double that of what it should be. All other bloods across an elaborate board were in range
In terms of symptoms – I had never felt better, I cannot even remember what it felt to be like this. I had high libido, energy in the gym, energy at work I had never had before, great ideas all the time, positive about everything. The only negatives you could say were a little nipple sensitivity, and the occasional emotional moment. I had night time wood that would wake me up in the night as it was so strong, as well as morning. This has since subsided (no morning/night wood anymore for last few weeks)
He wanted to put me on anastrozole to tame the E2 – I however requested if I could please do some other things before introducing another medication – as my T was high I suggested reduce the dose a bit, and increase the frequency of injection. He let me have a go
I reduce Test C down to 90mg per week, 7x per week
kept HCG the same at 1050iu (as per his recommendation) but changed to 7x per week.
I increased my exercise, I incorporated zinc, calcium and vitamin D sups, cod liver oil, multi vitamin; increased my intake of green veg, and reduced dairy and ensured I did not touch anything with any kind of soy. I also incorporated a natural oestrogen blocker called ‘estro-halt’ daily:
https://www.amazon.com/Estrohalt-Di...-Carbinol-Aromatase-Supplements/dp/B07D5FKLCL
I had the results back on the 27th October and my E2 had only reduced by 12%. Having dropped the Test C a tad, and spread the HCG, for some reason I do not feel as good as I did prior. I feel a thousand times better than before TRT, but in the first 6 weeks you could say I felt 10,000 times better… (sorry, exaggerating). I understand this to be probably down to the honeymoon period. However there could be a correlation with the reduced T dose, you guys will know better than me.
Test results on the 27th October were:
Total T at 41.3 (ref range 8.6 – 29).
Free T at 1.1 (ref range 0.2 – 0.62)
E2 at 221 (ref range 41 – 169)
Interestingly, even though I had reduced the Test C down to 90mg, I was reporting a higher T total and free. It could be before on the previous test it was the day after an injection day, whereas now every day is an injection day (this was the Dr. speculation). Again, he was not concerned about the higher T at the present moment due to it possibly being an irronious reading, and that I am having wondering symptom relief, but is dead set that the E2 needs to come down via the synthetic route as my regimen has not helped get it down.
Anyway trying to get to the point; I have tried to do what I can but have failed at reducing E2, and the dr has said I need to be prescribed anastrozole and see if we can get the E2 into normal range. It will be arriving in the mail tomorrow.
The dose prescribed is 0.25mg, twice a week. The pill comes in a 1mg and I am to break it into 4 using a pill cutter.
Reading these boards, that seems like a high starting point. And it appears there are several methods of breaking this down with alcohol to get a more accurate split and for micro dosing it down even more.
My question is:- what would you say my starting dose should be, given my bloods / age and weight above, and table below? in Your opinion / experience
Below are my bloods to date for ease of reading:
I am considering reducing the injection frequency just to EOD (still an improvement over 3DPW, but not as demanding and clearly not helping on being ED), if I am going to incorporate this anastrozole.
I would have thought it would be best to take the anastrozole at the same time as the Test shot? Or shortly thereafter? Not sure why twice a week makes any sense.
I am nervous of having my E2 crash and end up back to square 1 as I have read so many reports on here.
Logic to me says if I can have a lower dose of anastrozole than I am being prescribed, there is no harm in trying. And I can get bloods done in 2 weeks time for example and see where the E2 is. If its in range, and I am feeling fine – then surely stick to that, and report it to the dr. If E2 still not right, then increase the dose a tad more and try again. I am patient, but also nervous, and sceptical.
Any comments / advice would be much appreciated. Thank you for reading this far down!
I will also note before anyone says why not just ask the dr?. good question. I do not get good answers to questions I ask, and the ability to speak to them is few and far between. So I have to take what I can get, it is very challenging in the UK to get TRT so I’m happy enough to sort myself out
Many thanks
This is my first proper post – I am happy I found this place as it has been an interesting read for the last few days. I have gone over as many anastrozole / Adex posts/threads as I can but cannot quite find specifically what I am looking for, so I hope you do not mind me asking.
Some brief context:- I am 37 years old male, from the UK. 5’65 and 72kg (sorry for the mix of imperial / metric), in decent shape I go to the gym and eat a balanced healthy diet with a robust supplement regimen.
Edit before posting: I am going to cut my life story! Not relevant how I got here, but here I am
Prior to starting TRT, blood test no: 1 on 2nd July 2021:
Total T was 10.6 nmol/L (ref range 8.6 – 29)
Free T (FTI) 0.3 (ref range 0.2 – 0.62)
So In the gutter almost for 36 yrs old healthy male, at that time.
E2 was 80 (ref range 41 – 169) – normal I guess
2nd test on 10th August 2021:
Total T was 12 nmol/L (ref range 8.6 – 29)
Free T (FTI) was 0.2 (ref range 0.2 – 0.62)
E2 was 85 (ref range 41 – 169)
The dr concluded I had very low T and I could start TRT if I wanted.
I started TRT on the 21st August 2021
100mg of Test Cypionate, 3x PW, SubQ.
HCG 1050iu 3x PW (350iu per shot), SubQ, administered at the same time as the Test C.
After almost 6 weeks on this protocol I had a blood draw, and the results came back as follows
Total T at 36.6 (ref range 8.6 – 29).
Free T at 1.0 (ref range 0.2 – 0.62)
E2 at 235 (ref range 41 – 169)
Following the consultation, the Dr was not so concerned about my T being higher at the present moment, but was concerned my E2 was double that of what it should be. All other bloods across an elaborate board were in range
In terms of symptoms – I had never felt better, I cannot even remember what it felt to be like this. I had high libido, energy in the gym, energy at work I had never had before, great ideas all the time, positive about everything. The only negatives you could say were a little nipple sensitivity, and the occasional emotional moment. I had night time wood that would wake me up in the night as it was so strong, as well as morning. This has since subsided (no morning/night wood anymore for last few weeks)
He wanted to put me on anastrozole to tame the E2 – I however requested if I could please do some other things before introducing another medication – as my T was high I suggested reduce the dose a bit, and increase the frequency of injection. He let me have a go
I reduce Test C down to 90mg per week, 7x per week
kept HCG the same at 1050iu (as per his recommendation) but changed to 7x per week.
I increased my exercise, I incorporated zinc, calcium and vitamin D sups, cod liver oil, multi vitamin; increased my intake of green veg, and reduced dairy and ensured I did not touch anything with any kind of soy. I also incorporated a natural oestrogen blocker called ‘estro-halt’ daily:
https://www.amazon.com/Estrohalt-Di...-Carbinol-Aromatase-Supplements/dp/B07D5FKLCL
I had the results back on the 27th October and my E2 had only reduced by 12%. Having dropped the Test C a tad, and spread the HCG, for some reason I do not feel as good as I did prior. I feel a thousand times better than before TRT, but in the first 6 weeks you could say I felt 10,000 times better… (sorry, exaggerating). I understand this to be probably down to the honeymoon period. However there could be a correlation with the reduced T dose, you guys will know better than me.
Test results on the 27th October were:
Total T at 41.3 (ref range 8.6 – 29).
Free T at 1.1 (ref range 0.2 – 0.62)
E2 at 221 (ref range 41 – 169)
Interestingly, even though I had reduced the Test C down to 90mg, I was reporting a higher T total and free. It could be before on the previous test it was the day after an injection day, whereas now every day is an injection day (this was the Dr. speculation). Again, he was not concerned about the higher T at the present moment due to it possibly being an irronious reading, and that I am having wondering symptom relief, but is dead set that the E2 needs to come down via the synthetic route as my regimen has not helped get it down.
Anyway trying to get to the point; I have tried to do what I can but have failed at reducing E2, and the dr has said I need to be prescribed anastrozole and see if we can get the E2 into normal range. It will be arriving in the mail tomorrow.
The dose prescribed is 0.25mg, twice a week. The pill comes in a 1mg and I am to break it into 4 using a pill cutter.
Reading these boards, that seems like a high starting point. And it appears there are several methods of breaking this down with alcohol to get a more accurate split and for micro dosing it down even more.
My question is:- what would you say my starting dose should be, given my bloods / age and weight above, and table below? in Your opinion / experience
Below are my bloods to date for ease of reading:
Reference range | Low | High | 02-Jul-21 | 10-Aug-21 | 28-Sep-21 | 27-Oct-21 |
Oestradiol | 41 | 169 | 80.0 | 85.0 | 235.0 | 221.0 |
Testosterone (Total) | 8.6 | 29 | 10.6 | 12.0 | 36.6 | 41.3 |
Free Testosterone Index (FTI) | 0.2 | 0.62 | 0.3 | 0.2 | 1.0 | 1.1 |
Sex Hormone Binding Globulin (SHBG) | 18.3 | 54.1 | 40.1 | 32.0 | 23.0 | 25.0 |
I am considering reducing the injection frequency just to EOD (still an improvement over 3DPW, but not as demanding and clearly not helping on being ED), if I am going to incorporate this anastrozole.
I would have thought it would be best to take the anastrozole at the same time as the Test shot? Or shortly thereafter? Not sure why twice a week makes any sense.
I am nervous of having my E2 crash and end up back to square 1 as I have read so many reports on here.
Logic to me says if I can have a lower dose of anastrozole than I am being prescribed, there is no harm in trying. And I can get bloods done in 2 weeks time for example and see where the E2 is. If its in range, and I am feeling fine – then surely stick to that, and report it to the dr. If E2 still not right, then increase the dose a tad more and try again. I am patient, but also nervous, and sceptical.
Any comments / advice would be much appreciated. Thank you for reading this far down!
I will also note before anyone says why not just ask the dr?. good question. I do not get good answers to questions I ask, and the ability to speak to them is few and far between. So I have to take what I can get, it is very challenging in the UK to get TRT so I’m happy enough to sort myself out
Many thanks
Last edited:
