Pregnenolone Experiences

I am curious why some of you guys had good reactions to pregnenolone and why both times I used it it made me feel nuts. Is it possible TRT (no hcg here though) didn't shutdown my preg production? or maybe it converts to hormones I don't need? I've been taking preg almost whole winter (cream form) and whole this winter I was feeling quite shitty, then I stopped it and man how much better my life became. Any ideas? What were yours experiences with pregnenolone?
 
VC makes a good point about overuse of pregnenolone. I did supplement will 10mg of Pure Brand encapsulations pregnenolone for about 6 months and I felt that I received no benefits from it.
 
Yeah after reading of benefits that pregnenolone should give and the fact the many top trt doctors include it in protocol I thought maybe I should use it but my experience was quite negative. I guess everybody is different, I am 21 by the way so maybe there is enough pregnenolone in my body
 
I'm at the other end of the age spectrum, 59 years old, and my very brief use of it resulted in absolutely nothing. Not a thing one way or the other.
 
Well at least there were no detrimental effects... I gave some to my wife and she had to be hospitalised for blood clots in her legs! So I read up on it and sure enough it was mentioned. I'm already on cortisol so it does nothing for me but perhaps if your feeling crazy as one could feel with cushings disease its possible it creates too much cortisol for you.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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