PARTIALLY EMPTY SELLA & PEPTIDES: will they work?

mcs

Member
For the docs and endocrine wizards on board:

I have a partially empty sella [Empty sella syndrome - Wikipedia] as confirmed twice by two MRIs. Since I essentially have no or little pituitary gland left, would anyone know if secretagogue GH peptides (i.e. GHRH and GHRP) even work in my case? How to determine? I have not been diagnosed with hypopituitarism and my endocrine status is basically normal. My last IGF-1 was 221, however, past GH stim tests have shown mixed results.

From the endos I consulted with, not everyone with an empty sella presents with hormone deficiency.Conversely, just because you have normal labs on one day doesn’t mean you will the next. The fact that one has an empty sella in the first place leaves room for suspicion of some type of endocrinologic deficiency which is why I bring it up.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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