Ozempics Impact on Sexual Function

madman

Super Moderator


Today we are joined by Dr. Rahul Mehan, a renowned urologist, who sheds light on the impact of Ozempic on sexual function, particularly in relation to erectile dysfunction. He is also the founder of Snip City, which specializes in vasectomy procedures.

Ozempic, a semaglutide-based GLP-1 agonist, is widely recognized for its effectiveness in managing blood sugar and promoting weight loss, making it a popular choice among those battling obesity and diabetes. However, as its usage expands, there's growing interest in understanding its broader impacts, particularly on sexual function. Recent studies, though limited, have begun to shed light on potential side effects, including a modest increase in the incidence of erectile dysfunction and lower testosterone levels in some men using the medication.

The mechanism behind these effects remains unclear, though it's speculated that the drug's influence on brain receptors, which helps curb appetite and cravings, might also dampen sexual desire and function. This raises important questions about the overall sexual health of both men and women taking Ozempic, highlighting the need for further research and comprehensive patient screening by healthcare providers.
 
That certainly makes sense. From an evolutionary perspective, an animal in a calorie deficit wouldn't - and shouldn't - be focused on sex/procreation but rather survival.
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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