on trt with low e2

Blades

New Member
Been on trt (125mg test enth a week) for around 4 weeks now, beforehand my test was 14.1nmol..e2 146pmol and now that I've started trt my e2 is 26pmol or 7.1 in USA numbers...I was getting bad symptoms off high e2 then with lower t, and now I am getting bad symptoms off low e2...I can't understand how I've got low e2 now because I have quite abit of bodyfat...and my ring finger gets tighter...I done the blood test via medicheck in the UK , has anybody else used medicheck and are they reliable?.
 
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Been on trt for around 4 weeks now, beforehand my test was 14.1nmol..e2 146pmol and now that I've started trt my e2 is 26pmol or 7.1 in USA numbers...I was getting bad symptoms off high e2 then with lower t, and now I am getting bad symptoms off low e2...I can't understand how I've got low e2 now because I have quite abit of bodyfat...and my ring finger gets tighter...I done the blood test via medicheck in the UK , has anybody else used medicheck and are they reliable?.

What is your trt protocol and do you have pre-trt labs to post? Were you prescribed an aromatase inhibitor by your doctor treating you?
 
You asked about reliability and the lab that is testing your e2 values in the UK. I can't answer the question directly, since I live in in Canada, but I point out that you're not being tested with the LC, MS/MS, sensitive estradiol test (unless a revolution in androgen testing has taken place in Great Britain recently). I can't get that test in Canada either, I travel to the IS for it - not an option in your case. So...you and your doctor have to be carefully listening to symptoms and associating them with the results you can get. When are you testing relative to injection?
 
I don't whether it was a senitive e2 test, the DR said the machine or what ever can only detect down to 18.4pmol/L, but if it was checked by the senitive test surely the reading would only go down.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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