Nolvadex changed levels of hormones permanently

dzd

New Member
Hi

I have secondary hypogonadism due to some pituitary issues (maybe very very small rathke cleft cyst, or possible empty sella syndrome- doc are not sure). I had low T considering my age. Tried Clomid (1-50mg/ed; 2- 25mg/ed )twice over 2015 and my T as well as LH, FSH rise. But I did not feel quite good on it, beacuse clomid elevates my Acth, so cortisol as well(its important - even when I did not take clomid I got Acth slightly elevated, cortisol as well, I had problems with sleep during night). Also I got high level of aromatization(even if not on clomid).

Then in December 2015 I tried Tamoxifene (it was not from legal source), I read that 20mg Tamox. = 150mg clomid, so I divide pill for 4mg parts. Took it three days in a row. I had to stop took it due to shitty mood, sleeping 13 hours day, joints aches, I was very calm, patient as never (typical low E2 symptoms).

My levels of T stay at the same level or slightly elevate, but my E2 (which was between 35-45) drop to level 20-25. My cortisol due to (I think) lower E2 is now in range. Acth sometimes is elevated. I sleep 80-90 % better than before Tamoxifen. I became less nervous and I limit my cigarette smoking habit to 1 per mont (20 cigarettes/month before Tamox). My general frame of mind is better, but not perfect. I want to try clomid one more time in very low doses, maybe with lower aromatization it will work.

Does someone have nay thoughts ? I know that aromatization is occuring in liver, so maybe there is solution? Also I want to mention that half life of Nolva is the sam as Clomid.

05.2016
T - 3,77 ng/ml
Lh- 2,76
Fsh-1,27
Acth-68 (7-63)
Cortisol 16 (6-18)
E2-21

Before Nolva december 2015
T - 3,55 ng/ml
Lh- 2,95
Fsh-1,79
Acth-83 (7-63)
Cortisol 17 (6-18)
E2-32
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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