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I started a protocol simply with testosterone cypionate. I have a pituitary tumor, but my endo refused to prescribe injections, despite multiple low testosterone labs. I found a local bio-identical doctor, and he ran my labs again, and prescribed testosterone. Save me a bunch of money, cause I cant afford a mens clinic, while paying high bills for my other treatments. I felt good the very first month. I mean really strong, felt like I could chew nails! Now, I feel down, and just out of sorts. Ran labs a few weeks ago, and estrogen was under 20. I understand it wasnt the correct E2 lab, but my doctor says it wouldnt be too much of a difference. Total test was 1100, but was done two days after injections. I honestly think I dont have much estrogen anyway, due to the pituitary tumor. Anyhow, I read injections stop LH production, which helps produce pregnenlone and progesterone, which could impact my moods. I've read HCG stops this from happening. My question is couldnt I just take pregnenoline? My insurance wont cover HCG.
 
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Cataceous

Super Moderator
Regarding pregnenolone, yes, the theory is that it's supposed to help with "backfilling the pathways." But anecdotally there are not loads of reports from guys saying pregnenolone supplementation solved their problems. Not sure why that is; maybe it's not taking the right paths. Personally I am finding that TRT without hCG is an inferior experience compared to the combination, so I do recommend trying hCG if you're not happy with TRT alone.
 

captain

Active Member
I use HCG 150iu daily. I had labs done one time about a year ago. Didn't have labs from before HCG.

Pregnenolone 31 ng/dL Adults: <151
 

JimBob

Active Member
Regarding pregnenolone, yes, the theory is that it's supposed to help with "backfilling the pathways." But anecdotally there are not loads of reports from guys saying pregnenolone supplementation solved their problems. Not sure why that is; maybe it's not taking the right paths. Personally I am finding that TRT without hCG is an inferior experience compared to the combination, so I do recommend trying hCG if you're not happy with TRT alone.

Do you recommend guys start on TRT as a monotherapy at first?
 
Regarding pregnenolone, yes, the theory is that it's supposed to help with "backfilling the pathways." But anecdotally there are not loads of reports from guys saying pregnenolone supplementation solved their problems. Not sure why that is; maybe it's not taking the right paths. Personally I am finding that TRT without hCG is an inferior experience compared to the combination, so I do recommend trying hCG if you're not happy with TRT alone.
There's some sort of enzyme(?) dysfunction in the hypogonadal male, it seems to me, the number of guys that do not do well with HCG mimicing LH sufficiently to generate the downstream conversion. The same with Pregnenolone supplementation, or DHEA, etc etc
 

Cataceous

Super Moderator
Do you recommend guys start on TRT as a monotherapy at first?
I suppose so, because many guys seem to do well without hCG, and not using it saves them a decent amount of money over the years. I knew within a couple months that I didn't like the flat feeling and testicular atrophy I was getting with TRT mono.
 
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