New member--hello men

JRC

New Member
Hello all,

I found this forum last week and after reading some great information here, I decided to join. I'm 41 and I've always felt tired, fatigued and anxious through my entire adult life (two decades). I thought this was the biology given to me and I need to put up with it.

But it was a miserable existence, I didn't have the drive to get off the bed in mornings and seize the day. No morning wood. Erectile issues as well. There were only sporadic bursts of productivity (such as a project deadline), but the next day I will feel completely exhausted. I started lifting since 35 and optimized my nutrition, it was helpful to get rid of fat and I usually feel good in those days.

After reading the forum, I went ahead and did a blood panel. Here are the results:

Total T: 715 ng/dL
Free T: 1.79% (12.8 ng/dL)
Bioavailable T: 37.3% (267 ng/dL)
SHBG: 51.06 nmol/L
Albumin: 3.8 g/dL
E2/Estradiol: 57.42 pg/mL
Prolactin: 9.00 ng/mL

My total T seems decent. However, high E2 & SHBG levels and a below average Free T. Planning to take the results to a doctor next week, In the meantime, anyone here could chime in with the interpretation of these numbers.

Thanks!
 
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I would get a complete thyroid panel with reverse T3, check your A1C and fasting glucose. Vit D and magnesiium levels?
 
Welcome new member,

You will require a knowledgeable doctor in order to truly understand what those numbers mean, most just don't know much about male hormones, especially the SHBG connection and how it's intertwined with our Total T and free T. Low thyroid hormones go hand in hand with depression and anxiety, more times than not people are scripted SSRIs when what's need is thyroid hormones.

Order at least a full thyroid panel checking Free T3, Free T4, Reverse T3 and antibodies. It's nice to have these before the doctors appointment so the discussion is more productive and action can be taken sooner. Your free T needs to be 2-3% which is considered normal, Total T means nothing if your free hormones are low.
 
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Welcome to Excelmale. You mentioned, and referenced the results, of your estradiol test. Which test, ECLIA or LC, MS/MS (standard or sensitive), was run? The sensitive is the only e2 test men can rely on. If you are uncertain, lost the reference ranges; that's a dead giveaway.
 
I would get a complete thyroid panel with reverse T3, check your A1C and fasting glucose. Vit D and magnesiium levels?

Nice first post. Thank you!

Welcome new member,

You will require a knowledgeable doctor in order to truly understand what those numbers mean, most just don't know much about male hormones, especially the SHBG connection and how it's intertwined with our Total T and free T. Low thyroid hormones go hand in hand with depression and anxiety, more times than not people are scripted SSRIs when what's need is thyroid hormones.

Order at least a full thyroid panel checking Free T3, Free T4, Reverse T3 and antibodies. It's nice to have these before the doctors appointment so the discussion is more productive and action can be taken sooner. Your free T needs to be 2-3% which is considered normal, Total T means nothing if your free hormones are low.

Welcome to Excelmale. You mentioned, and referenced the results, of your estradiol test. Which test, ECLIA or LC, MS/MS (standard or sensitive), was run? The sensitive is the only e2 test men can rely on. If you are uncertain, lost the reference ranges; that's a dead giveaway.

Thanks for your replies, Vince, Matt, Systemlord & CoastWatcher. I only posted T-panel results; apologies. Just noticed the Blood Panel Discussion sub-forum. I'll post my full results there. Thanks!
 
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hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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