New Labs Estradiol way high (feedback welcomed)

I just got my labs back. looking at the results I am not completely sure they ran the sensitive test, but when I was there the lab tech said that was what was ordered. I am getting the results from online so I wonder if they just typed the Estradiol in wrong. I might have to go to the lab and ask for a result copy to be sure.

Component Standard Range Your Value

[TD="class: nameCol srchbl"]Estradiol[/TD]
[TD="class: infoCol"] 7.6 - 42.6 pg/mL[/TD]
[TD="class: importantCol"]98.6[/TD]

[TD="class: srchbl, colspan: 3"]Roche ECLIA methodology[/TD]

ComponentStandard RangeYour Value

[TD="class: nameCol srchbl"]T3, Free[/TD]
[TD="class: infoCol"]2.0 - 4.4 pg/mL[/TD]
[TD="class: importantCol"]3.4[/TD]



ComponentStandard RangeYour Value

[TD="class: nameCol srchbl"]TSH[/TD]
[TD="class: infoCol"]0.450 - 4.50 uIU/mL[/TD]
[TD="class: importantCol"]4.910[/TD]

[TD="class: nameCol srchbl"]T4,FREE (DIRECT)[/TD]
[TD="class: infoCol"]0.82 - 1.77 ng/dL[/TD]
[TD="class: importantCol"]1.15[/TD]

ComponentStandard RangeYour Value

[TD="class: nameCol srchbl"]Testosterone[/TD]
[TD="class: infoCol"]348 - 1197 ng/dL[/TD]
[TD="class: importantCol"]1098[/TD]

[TD="class: nameCol srchbl"]Comment[/TD]
[TD="class: infoCol"] [/TD]
[TD="class: importantCol"]Comment[/TD]

[TD="class: srchbl, colspan: 3"]Adult male reference interval is based on a population of lean males
up to 40 years old.[/TD]

[TD="class: nameCol srchbl"]Testosterone, Free[/TD]
[TD="class: infoCol"]7.2 - 24.0 pg/mL[/TD]
[TD="class: importantCol"]49.8[/TD]
 
According to the theory that the ratio of E2 to total T is more important than a static E2 number, you are not too high. Total T / E2 = Ratio where 14-20 is the ideal range. In your case, 1098 total T divided by E2 of 98 = 1098/98.6 = 11.13, which is in the ideal range.

More importantly, how do you feel? Do you have any high E2 symptoms? If not, then I would not adjust anything and or you may not have had the Sensitive E2 test.
 
Last edited:
TSH is way way elevated and points possible Hypothyroidism.

You need a complete and full work up done ASAP:

TSH
FT4
FT3
RT3
Antibodies

Your FT4 and FT3 look fine but sometimes you can't tell what really going on till you look at RT3 and Thyroid antibodies as well.
 
I agree with Gene. I would definitely check thyroid antibodies to see if you have Hashimoto's.

Your estradiol may (or may not be ) under 50% of that ECLIA value if you run a sensitive assay. That depends on the amount of CRP you have.

Your free T is good. Are you taking an anabolic steroid or any oral medications that you have not listed?
 
TSH is way way elevated and points possible Hypothyroidism.

You need a complete and full work up done ASAP:

TSH
FT4
FT3
RT3
Antibodies

Your FT4 and FT3 look fine but sometimes you can't tell what really going on till you look at RT3 and Thyroid antibodies as well.

Hi Gene,
I do take thyroid medication already. I have a call next week with Defy to talk about my tests. I might have to go to the lab and get them to look up the test. I asked when they were doing the draw and they said the Estrodoil was the sensitive test.
 
I agree with Gene. I would definitely check thyroid antibodies to see if you have Hashimoto's.

Your estradiol may (or may not be ) under 50% of that ECLIA value if you run a sensitive assay. That depends on the amount of CRP you have.

Your free T is good. Are you taking an anabolic steroid or any oral medications that you have not listed?

I take a few meds: , Metformin, thiroid med, DHEA and Uloric for gout.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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