negatives and risks of not backfilling the pathway [DHEA, PREG]

[lowe2sucks]

What are the negatives to not backfilling the pathways and not taking DHEA and pregnenolone on trt? Any long term risk doing so?

 

[Vince Carter]

Backfilling is overhyped, IMHO. DHEA more than Preg, can be not well tolerated in a lot of guys, aromatases easily, etc. But like all of this some love DHEA, some love Preg, and some like me avoid it entirely. There are no negatives to not supplementing...it's like one of these things that (IMHO) it's treating a number on a lab page vs is it really necessary to do it.

 

[Vince]

I know we have many threads on back filling the pathways, but many members cannot deal with the HCG and DHEA because of estrogen levels or sleep issues. I think back filling is a very individual thing, I do supplement with 25 mg of DHEA daily and 500 IU of HCG every 3 1/2 days. But that's me.

 

[Nelson Vergel]

Effect of TRT vs hCG/FSH on upstream hormone pathways.

The role of gonadotropins in testicular and adrenal androgen biosynthesis pathways -insights from males with congenital hypogonadotropic hypogonadism on hCG/rFSH and on testosterone replacement SUMMARY Objective: To delineate the role of gonadotropins in male androgen biosynthesis pathways...

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