Navigating Menopause: Unraveling the Impact on Mood

madman

Super Moderator
SUMMARY

The transition to menopause and early postmenopausal years may be quite challenging for some women, with the increased risk for developing depressive symptoms (new, recurrent) and anxiety, along with vasomotor complaints, sleep problems, and other menopause-related health conditions. It is fundamental that health professionals providing care for women during midlife years are prepared to recognize this window of vulnerability and to manage it accordingly. Importantly, neither depression nor anxiety during midlife years should be managed in isolation. Sleep problems, cognitive complaints, sexual dysfunction as well as the occurrence of context-related life stressors should be taken into consideration for the development of comprehensive, effective treatment plans.

It is now well established that estrogen plays an important neuromodulatory role— on the one hand, E2 fluctuations may contribute to the emergence of depression and anxiety symptoms; on the other hand, E2-based therapies may in fact alleviate these conditions, particularly when administered to symptomatic women in the menopausal transition and early postmenopausal years and/or experiencing increasing anxiety and stress during times of intense E2 fluctuations.

Antidepressants and behavioral therapies remain, however, the treatments of choice for depression and anxiety across the life span, including midlife years.
 

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KEY POINTS

*Depression is a prevalent, disabling condition

*Mid-life women are more vulnerable to develop depression (new onset or recurrent), often associated with vasomotor symptoms and sleep problems

*Therapies should be tailored to alleviate all these symptoms and improve quality of life, while taking into consideration pharmacologic, behavioral, and/or hormonal options
 
CLINICS CARE POINTS

*Some women may experience a ‘window of vulnerability” for the development of mood and anxiety symptoms during the menopause transition

*The presence and severity of vasomotor symptoms, sleep disturbances and cognitive changes should be taken into consideration when reviewing treatment options for symptomatic midlife women suffering from depression

*Evidence-based treatments include pharmacologic, hormonal and behavioral options; treatment should be tailored to patients' needs, taking into account efficacy, safety and tolerability
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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