Nandrolone for CRPS/RSD

[PAUL-E]

description of CRPS https://en.wikipedia.org/wiki/Complex_regional_pain_syndrome

Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), "causalgia", or reflex neurovascular dystrophy (RND) is an amplified musculoskeletal pain syndrome (AMPS). It is a chronic systemic disease characterized by severe pain, swelling, and changes in the skin. CRPS often worsens over time. It may initially affect an arm or leg and spread throughout the body; 35% of people report symptoms throughout their whole body.
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"Stage" one is characterized by severe, burning pain at the site of the injury, muscle spasms, joint stiffness, restricted mobility, rapid hair and nail growth, and vasospasm. The vasospasm is that which causes the changes in the color and temperature of the skin. Some may experience hyperhydrosis (increased sweating). In mild cases this stage lasts a few weeks, in which it can subside spontaneously or respond rapidly to treatment (physical therapy, pain specialist).
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"Stage" two is characterized by more intense pain. Swelling spreads, hair growth diminishes, nails become cracked, brittle, grooved, and spotty, osteoporosis becomes severe and diffuse, joints thicken, and muscles atrophy.
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"Stage" three is characterized by irreversible changes in the skin and bones, while the pain becomes unyielding and may involve the entire limb. There is marked muscle atrophy, severely limited mobility of the affected area, and flexor tendon contractions (contractions of the muscles and tendons that flex the joints). Occasionally the limb is displaced from its normal position, and marked bone softening and thinning is more dispersed.
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supporting information I could find:
http://www.dissertationtopic.net/doc/1856753
https://books.google.com/books?id=q...Q6AEIHDAA#v=onepage&q=nandrolone CRPS&f=false

Nandrolone is known for joint pain relief and can prescribed off label for osteoporosis so why not CRPS/RSD?
I would like to see human study's on this as I believe it would be beneficial and could be preventative of bone mineral density loss.
What do you think?

 

[PAUL-E]

Just wanted to add http://www.ncbi.nlm.nih.gov/pubmed/11470933
CONCLUSION:

Our results show significant reduction of BMD in patients with CRPS-I after stroke. The reduction in BMD correlates with the severity of shoulder hand syndrome score, degree of weakness, duration of hemiplegia, and the severity of stroke
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Nandrolone slows hindlimb bone loss in a rat model of bone loss due to denervation.
http://www.ncbi.nlm.nih.gov/pubmed/20392251
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Osteopathic changes sometimes occur in patients with complex regional pain syndrome (reflex sympathetic dystrophy and causalgia).
http://www.ncbi.nlm.nih.gov/pubmed/11862530

 

[ERO]

This makes perfect sense, but the 'war on steroids' keeps it out of reach.

 

[PAUL-E]

Thanks for the reply. I agree did you see this?
https://www.excelmale.com/forum/showthread.php?6519-Video-The-War-on-Anabolic-Steroids

 

[PAUL-E]

I am in the process of working with a place to see if this would be a possible treatment option for me if it works out and I am able to try the medication I will post my experience.

 

[Nelson Vergel]

Paul-E

Just make sure you use a good TRT dose with it since it will decrease your own T production if you are not on TRT.

200 mg per week is a conservative dose. Like T, anabolics can decrease HDL and increase hematocrit, so keep an eye on those two parameters.

Some people speculate that nandrolone can increase prolactin. I have not seen evidence on that but you may want to test your prolactin 4 weeks after starting nandrolone plus TRT.

lipids, CBC and prolactin are available on http://www.discountedlabs.com/choose-your-test/

 

[PAUL-E]

Thanks nelson that's a very good point. It seems like most people who get CRPS/RSD end up needing testosterone replacement therapy whether its from various medication like opioids or other things.

Side effects with opioids are common and can be problematic. Common opioid side effects, particularly with higher doses, include nausea, vomiting, constipation, cognitive impairment, and somnolence. More serious side effects can include respiratory depression and, in a small subset of patients, addiction. The dilemma with long-term opioid use in CRPS is that prolonged use of opioids may result in problems including tolerance, hyperalgesia [26], hormonal effects (decreased testosterone levels, decreased libido and sex drive, irregular menses) [27], and suppression of the immune system. Consequently, although opioid treatment may be prescribed to reduce pain and improve function, the treatment may lead to more pain and dysfunction in some patients.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914598/

I have also read if you do get prolactin issues you can use dostinex(cabergoline) to lower prolactin and improve sexual function.
http://www.ncbi.nlm.nih.gov/pubmed/14764772
http://www.ncbi.nlm.nih.gov/pubmed/16728967
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367515/

 

[maxadvance]

Paul-E

Just make sure you use a good TRT dose with it since it will decrease your own T production if you are not on TRT.

200 mg per week is a conservative dose. Like T, anabolics can decrease HDL and increase hematocrit, so keep an eye on those two parameters.

Some people speculate that nandrolone can increase prolactin. I have not seen evidence on that but you may want to test your prolactin 4 weeks after starting nandrolone plus TRT.

lipids, CBC and prolactin are available on http://www.discountedlabs.com/choose-your-test/

I thought there was clear evidence that Deca raises prolactin levels, but pronounced when dosing is 300mg per week or higher. 200mg per week is def a conservative dose. I had DiscountedLabs run my prolactin, it was 37, but have no ED issues.

 

[PAUL-E]

One of the links is no longer working so I copyed it http://webcache.googleusercontent.c...ontopic.net/doc/1856753&num=1&strip=1&vwsrc=0
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Experimental Research of Nandrolone Phenylpropionate in the Treatment of CRPS on the Rat Model
Author: YangYang
Tutor: NanFeng
School: Dalian Medical University
Course: Surgery
Keywords: complex regional pain syndrome nandrolone phenylpropionate salmon calcitonin substance P bone mineral density
CLC: R965
Type: Master's thesis
Year: 2012
Downloads: 8
Quote: 0
Read: Download Dissertation
Abstract
Objective: This research is intended to evaluate the analgesic effect of nandrolone phenylpropionate on the rat model of complex regional pain syndrome, and briefly discuss the analgesic mechanism of the nandrolone phenylpropionate, so as to provide the experimental evidence for clinical application of phenylpro-pionate nandrolone in the treatment of complex regional pain syndrome. Methods: Forty-eight healthy adult SD rats were randomly divided into four groups equally. Rats were anesthetized over a3h period with chloral hydrate. After induction of anesthesia, a O-ring with5mm internal diameter was placed around the rat’s right hind limb just proximal to the ankle joint. The O-rings were selected to produce a tight-fit pressure about350mmHg,and were left on the limb for3h. The rats in the sham group received exactly the same treatment,except that the O-ring loosely surrounded the ankle, and did not occlude blood flow to the hind paw. Rats of group B were injected with1ml sterile water intraperitoneally every other day, to days-21aftersurgery. Rats of group C were injected with salmon calcitonin（2IU/Kg） intraperitoneally, every other day, to days-21after surgery. And rats of group D were injected with nandrolone phenylpropionate （5mg/Kg） intraperitoneally, every other day, to days-21after surgery. Then general observation, pain behavior, serum substance P, and distal bone mineral density of the tibia were measured at the specific observation points. By the above indicators, assessing the analgesic effect of nandrolone phenylpropionate on rat model of complex regional pain syndrome. All experimental data were analyzed by the software of SPSS12.0.Results:1.General observation: After modeling, the rats in group B, C and D had a limping gait. At weeks-3after surgery, the claudication symptom of the rats in group C and D was better than the rats in group B. And the rats in group B had epilation and scaling phenomenon.2.Spontaneous pain: At one day after the modeling, spontaneous pain was checked. The spontaneous pain of injured group is more serious than the group A（p＜0.05）.3.Mechanically induced pain: Since the7days after modeling, the pain threshold of group C and D was significantly higher than group B（p＜0.05）. To days-21aftersurgery, no significant difference was found between the two treatment groups and group A. At each observation point, no significant difference was found between group C and group D.4.Paw withdrawal latency: Since the7days after modeling, the paw withdrawal latency of group C and D was significantly higher than group B （p＜0.05）,but always lower than group A. At each observation point, no significant difference was found between group C and group D.5.Substance P: Since the7days after modeling, the level of substance P of group C and D was significantly lower than group B（p＜0.05）, but always higher than group A. At each observation point, no significant difference was found between group C and group D.6.The tibia Ca2+average density testing: At twenty-one days after the modeling, the distal Ca2+average density of the right tibia of group B is significantly lower than group A（p＜0.05）. No significant difference was found in other groups.Conclusion:1.Ischemia reperfusion model can simulate the pathophysiological process of CRPS, and modeling process is easy to operate.2.Since the7days after modeling, nandrolone phenylpropionate can signifi-cantlyimprove pain behavior index of the experimental animal, and reduce the expression of substance P.3.Nandrolone phenylpropionate can increase the local Ca2+average density and muscle strength of experimental animal, and prevent the development of CRPS. In summary, the study shows that nandrolone phenylpropionate has a good effect on CRPS with the rat model. So the clinical efficacy of nandrolone phenylpropionate is worthy of further experimental study.

 

[Nutpuncher]

I am living proof that chronic opiod use (abuse in my case) caused my life to and my natural testosterone to hit rock bottom. My lowest TT before starting TRT was 145 (range 345-1197). I am also on successful low dose DECA 100mg a week to reduce golfer elbow pain.
joint pain relief

Read more at: https://www.excelmale.com/forum/showthread.php?6554-Nandrolone-for-CRPS-RSD&p=38373#post38373

joint pain relief

Read more at: https://www.excelmale.com/forum/showthread.php?6554-Nandrolone-for-CRPS-RSD&p=38373#post38373

 

[PAUL-E]

Hey nutpuncher when I click on your links they just bring me back to this page?

 

[Nutpuncher]

Hey nutpuncher when I click on your links they just bring me back to this page?

so weird...I never entered those links....I have no idea how it got there...unless I was recklessly copying and pasting lol.

So please disregard those links

 

[PAUL-E]

I just wanted to add after reading nelsons posts https://www.excelmale.com/forum/sho...-Uses-Presentation-Attached&p=38617#post38617 on Oxandrolone I believe it too might be beneficial for CRPS.

 

[PAUL-E]

I've been given the opportunity to do a trial run of nandrolone to see if it will provide some symptom relief. I have been prescribed a total of 120MG of nandrolone a week.
MY new protocol 3x a week
50mg testosterone total 150mg per week
300iu's of HCG total 900IU's a week
40MG of nandrolone deaconate total 120mg a week
I will update after a few weeks to let you know how it works out!

 

[Nelson Vergel]

Paul-E

It looks like a very reasonable and conservative protocol. Please keep us updated. Thanks

 

[Vettester Chris]

Looks like a familiar protocol!! Keep us posted please.

 

[PAUL-E]

I will be starting the medication tomorrow. I am not a DR. this is my opinion, to reiterate I believe the main benefits of Nandrolone Decanoate for CRPS/RSD are:
anti inflammatory properties
preservation of BMD
prevent/reverse muscle atrophy
preserve/improve joint mobility
improve quality of life

 

[maxadvance]

FYI, Deca normally takes awhile to kick in, 6 weeks to feel full effect.

 

[PAUL-E]

Review of Nandrolone for CRPS
Fist let me say I have tried MSM, Glucosamine, Chondroitin, Vitamin C, Vitamin D3, Magnesium, Potassium, Gelatin, Turmeric, Curcuma Longa Rhizome/Glycine, Collagen Type II, ApresFlex, Horsetail Herb, BioPerine, Boron and others to try and help with joint mobility/pain with little to no help.
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what have I noticed/observed?
improved joint mobility
reduced joint aching
improved pinch/grip strength
improved mood/sense of well being
improved quality of life
Some things I have noticed but should be given more time to be sure are reduced swelling both in times and severity, reduced red blotchy look that ussualy happens more with the swelling and the part of my hand that was crushed was noticabley colder to touch that seems to have improved as well although it is summer time and a true test will be this winter.
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I still have to wait and check hematocrit and HDL but no negative side effects to report as of yet besides and increase in hunger that very well could have been due to change it diet but it has sense leveled off and is no longer an issue.
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For straight pain relief Lyrica (pregabalin) was more effective but not worth the severe negative side effects that I experienced and that can cause other health issues IMO. I still have issues with hypersensitivity and have to be very careful with activity but it has helped improved the quality of my life and I'm thankful to have been able to try it and plan on continuing to use this medication.
I hope more doctors will be open to the use of this medication and that this review will help others suffering with CRPS.
I will update with any changes.

 

[Nelson Vergel]

Thanks for the update, Paul-E. I am glad your experiment with nandrolone is working for you!