Creatine as Cancer Fighter

Will Brink

Member
Yet another potential benefit of creatine is that of an essential immune support supplement via energy for antitumor immunity. While this is a mouse model, there’s no reason to think it does not apply to humans as the cellular mechanisms are essential the same:

“...our results have identified creatine as an important metabolic regulator controlling antitumor T cell immunity, underscoring the potential of creatine supplementation to improve T cell–based cancer immunotherapies.”

So what does that mean? T cells need large amounts of energy to fight cancer, and it’s known they can suffer what’s called T-cell exhaustion. They literally run out of energy while attempting to fight cancer. As creatine is an essential molecule in energy production for all cells, it also acts as “molecular battery,” wherein stored energy helps these essential immune cells from simply running out of steam to fight on. More data is needed to be sure, but as it has such a long list of known benefits, this may be yet one more. The data also suggests that creatine may improve outcomes for those with cancer being treated via T cell–based cancer immunotherapies. Amazingly, feeding mice the dose of creatine typical of what humans ingest, they demonstrated the mice then had ability to suppress both colon and skin cancer growth.

Source and link to paper, etc:

Creatine As Cancer Fighter? | BrinkZone.com
 

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A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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