Moving from HCG Mono to TRT+HCG

Tommy5454

New Member
Hi guys, I promised I searched for an hour and didn’t find the answer, in case it is in a thread somewhere obvious. I am on HCG mono with decent results, but i need my T to be a little higher and E to be a little lower based on how I feel and bloodwork taken based on those feelings.

When decreasing HCG and adding TRT, do I do both at once, or do I need to decrease HCG for a certain amount of time before starting TRT? If so, how long?

Thanks.
 
As I understand, hCG is a fast acting hormone as is LH both being glycoproteins, meaning they are soluble in plasma and act quickly on the cell receptors on the outside of cells. Whereas testosterone being lipid-soluble remains bound to carriers in the blood and has to penetrate the cell membrane to have its effects within the cell, so it is slower acting. Therefore, hCG should not be exerting much effect after a few days as its half life is about 2-3 days.
However, the testosterone it has signaled to be produced by your testes will hang around for a little longer.
So in short, I don't think you would have an issue doing both at once.
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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