More testosterone the better

Well at least according to Dr Ty Vincent.



 
The combination of targeting 2000 ng/dL together with aromatase inhibition tells me this guy will do great harm over his career, though it may not be apparent in the short-term. CVD is a slow burn.
Yeah. I thought that the increase in estradiol and DHT were the main benefits of TRT as long as they don't increase too much. But how do we know what is too much or too little estradiol and DHT? Do we just go by feel and ignore the reference ranges? Some guys feel great on trans-scrotal cream with DHT 100 x above the upper range while others feel way too revved up and aggressive with such high DHT. Some guys can tolerate 500iu hCG twice a week along with 50mg test cyp twice a week while other guys can't tolerate hCG at any dose.
Dr Ty Vincent said he feels best on 250mg test every 3 days. That's a bodybuilding dose for sure. No wonder he needs to control his estradiol. He didn't mention how much arimidex he takes but did say he's been on that protocol for 16 years and all his other health biomarkers are good.
If he takes just enough arimidex to keep his sensitive estradiol within the normal range, is there enough evidence he is harming himself?
 
But how do we know what is too much or too little estradiol and DHT? Do we just go by feel and ignore the reference ranges?
Yes, that is what I would suggest. And as long as you control those metabolites with your testosterone dose and administration method, as opposed to inhibiting 5 alpha reductase or aromatase, you are playing within healthy boundaries IMO.
 
The combination of targeting 2000 ng/dL together with aromatase inhibition tells me this guy will do great harm over his career, though it may not be apparent in the short-term. CVD is a slow burn.

Even without the AI these testosterone levels put enzyme saturation effects in play—with the potential to create all kinds of imbalances. For example, aside from altering relative androgen/estrogen activity there's possible competitive inhibition of neurosteroid formation. The use of normal physiological ranges to diagnose dysfunction and disease is not arbitrary.
 

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