The study was a 2 x 2 factorial design where older men were given 100 mg of testosterone a week or not and were eating 1.3 g/kg or 0.8 g/kg (the RDA) of protein a day. No mention is made in the summary of any exercise program, but the summary says the men were "functionally limited." The men were followed for 6 months. As you can see from the graph, testosterone significantly increased lean body mass, but there was no benefit from additional protein.
This randomized clinical trial with a 2 × 2 factorial design was conducted in a research center. A modified intent-to-treat analytic strategy was used. Participants were 92 functionally limited men 65 years or older with usual protein intake less than or equal to 0.83 g/kg/d within the RDA.
The first participant was randomized on September 21, 2011, and the last participant completed the study on January 19, 2017.
Participants were randomized for 6 months to controlled diets with 0.8 g/kg/d of protein plus placebo, 1.3 g/kg/d of protein plus placebo, 0.8 g/kg/d of protein plus testosterone enanthate (100 mg weekly), or 1.3 g/kg/d of protein plus testosterone. Prespecified energy and protein contents were provided through custom-prepared meals and supplements.
Among 92 men the 4 study groups did not differ in baseline characteristics. Changes from baseline in lean mass, as well as muscle strength and power, walking speed and stair-climbing power, health-related quality of life, fatigue, and well-being, did not differ between men assigned to 0.8 vs 1.3 g/kg/d of protein regardless of whether they received testosterone or placebo.
Fat mass decreased in participants given higher protein but did not change in those given the RDA: between-group differences were significant.
The summarycan be read online. The full article is behind a paywall.
This randomized clinical trial with a 2 × 2 factorial design was conducted in a research center. A modified intent-to-treat analytic strategy was used. Participants were 92 functionally limited men 65 years or older with usual protein intake less than or equal to 0.83 g/kg/d within the RDA.
The first participant was randomized on September 21, 2011, and the last participant completed the study on January 19, 2017.
Participants were randomized for 6 months to controlled diets with 0.8 g/kg/d of protein plus placebo, 1.3 g/kg/d of protein plus placebo, 0.8 g/kg/d of protein plus testosterone enanthate (100 mg weekly), or 1.3 g/kg/d of protein plus testosterone. Prespecified energy and protein contents were provided through custom-prepared meals and supplements.
Among 92 men the 4 study groups did not differ in baseline characteristics. Changes from baseline in lean mass, as well as muscle strength and power, walking speed and stair-climbing power, health-related quality of life, fatigue, and well-being, did not differ between men assigned to 0.8 vs 1.3 g/kg/d of protein regardless of whether they received testosterone or placebo.
Fat mass decreased in participants given higher protein but did not change in those given the RDA: between-group differences were significant.
