More Frequent Injections and E2 and HCT

MikeXL

Member
I have heard that more frequent injections may result in less conversion to E2 and better control of HCT. I have also heard that more frequent injections can result in a smaller total dose for the week. For example, someone injecting 150 per week may only need 16 per day (total of 112 for the week).


My question is - why do more frequent injections result in less conversion to E2 and better control of HCT? Is it because injecting more frequently lessens the peaks or is it because injecting more frequently involves using less testosterone in total?
 
I would think less spiking, it seems most do good injecting every 3 1/2 days. But I do know some inject daily and they seem to thrive on it.
 
I have been injecting daily for about a week now (.10 cc of Test Cyp (2000MG/10ML)). I am feeling really good. I am using an 28G 1/2" insulin pin and with this amount the pins are quick and painless. I have had elevated E2 and I wanted to try dailies before being prescribed an AI. I plan on doing my labs at the 4 week mark to see where I am at. The only down side so far is that my Sharps container is filling up quick.
 
Ten months ago I went from 60mg every 3.5 days to 16mg every morning. My E2 dropped nicely and my testosterone level (at trough) dropped from slightly over 1000 to the mid-900s. I wanted to avoid an AI, I did (I never had an issue with hematocrit or hemoglobin). Nice, steady-state levels. No peaks, no troughs, no AI. I've not looked back.
 
But when they move to daily do they lower their total weekly amt?

Yes, I did. My doctor and I wanted to mimic what the typical, healthy male body produces on a daily basis. Adjusting for the carbon chain, the ester, it did result in somewhat less testosterone injected over the course of the week.
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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