Molecular basis of androgen action on human sexual desire

madman

Super Moderator
6. Conclusion

Sexual arousal and desire are physiological and motivational issues important for reproduction. Neurosteroids, pheromones, lysosphingolipids and other molecules contribute at establishing the physiological sexual response in both sexes. In humans, sexual behaviours may be distinct from reproductive behaviours and rely mainly on the action of testosterone on membrane and nuclear receptor localized in the brain and peripheral tissues. Sexual desire is a central event for reproduction and is dependent on the action of testosterone at the brain level in both men and women. The sexual stimulus is cognitively recognized and activates autonomic cerebral centres by acting on somatic afferent pathways, leading to increased neural activity in specific cortical areas. The AR exists in various genetic variants providing different cell response to the hormone and a wide range of phenotypes featuring own sexual behaviours. These phenotypes may be linked to specific reproductive strategies relying on propensity to kin care or competition for mating.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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