Molecular basis of androgen action on human sexual desire

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madman

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6. Conclusion

Sexual arousal and desire are physiological and motivational issues important for reproduction. Neurosteroids, pheromones, lysosphingolipids and other molecules contribute at establishing the physiological sexual response in both sexes. In humans, sexual behaviours may be distinct from reproductive behaviours and rely mainly on the action of testosterone on membrane and nuclear receptor localized in the brain and peripheral tissues. Sexual desire is a central event for reproduction and is dependent on the action of testosterone at the brain level in both men and women. The sexual stimulus is cognitively recognized and activates autonomic cerebral centres by acting on somatic afferent pathways, leading to increased neural activity in specific cortical areas. The AR exists in various genetic variants providing different cell response to the hormone and a wide range of phenotypes featuring own sexual behaviours. These phenotypes may be linked to specific reproductive strategies relying on propensity to kin care or competition for mating.
 

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