Metformin potential COVID-19 therapeutic agent

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Metformin has been identified as a potential COVID-19 therapeutic agent because of its possible action against the proteins that are involved in translation, its antiviral activity in vitro, and its anti-inflammatory and antithrombotic activities.

 
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  1. Karam BS, Morris RS, Bramante CT, et al. mTOR inhibition in COVID-19: a commentary and review of efficacy in RNA viruses. J Med Virol. 2021;93(4):1843-1846. Available at: mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses - PubMed.
  2. Del Campo JA, García-Valdecasas M, Gil-Gómez A, et al. Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy. PLoS One. 2018;13(1):e0191805. Available at: Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy - PubMed.
  3. Postler TS, Peng V, Bhatt DM, Ghosh S. Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism. Sci Rep. 2021;11(1):18721. Available at: Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism - PubMed.
  4. Xin G, Wei Z, Ji C, et al. Metformin uniquely prevents thrombosis by inhibiting platelet activation and mtDNA release. Sci Rep. 2016;6:36222. Available at: Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release - PubMed.
  5. Li Y, Yang X, Yan P, et al. Metformin in patients with COVID-19: a systematic review and meta-analysis. Front Med (Lausanne). 2021;8:704666. Available at: Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis - PubMed.
  6. Bramante CT, Buse J, Tamaritz L, et al. Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity. J Med Virol. 2021;93(7):4273-4279. Available at: Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity - PubMed.
  7. Luo P, Qiu L, Liu Y, et al. Metformin treatment was associated with decreased mortality in COVID-19 patients with diabetes in a retrospective analysis. Am J Trop Med Hyg. 2020;103(1):69-72. Available at: Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis - PubMed.
  8. Reis G, Dos Santos Moreira Silva EA, Medeiros Silva DC, et al. Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: the TOGETHER randomized platform clinical trial. Lancet Reg Health Am. 2022;6:100142. Available at: Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: The TOGETHER randomized platform clinical trial - PubMed.
  9. Bramante CT, Huling JD, Tignanelli CJ, et al. Randomized trial of metformin, ivermectin, and fluvoxamine for COVID-19. N Engl J Med. 2022;387(7):599-610. Available at: Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19 - PubMed.
 
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