Metformin Decreases Aerobic Capacity, Muscle Mass and Testosterone

I have been on 2x1000mg a day but I lost my endurance(Kun Khmer/Muay Thai training) and workout capacity/volume. I had no common sides from it, no diarrea etc, but felt physically limited.
A strange feeling of being limited by the amount of energy the body had stored or could generate on the mitochondrial level. More like a cellular exhaustion. Stopped taking it after 5 months and have not experienced that any longer. I do still like the promise of Metformin and will use it again when I will slow down...... (ends with a 2-min cameo by @nelsonvergel)

Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max - Excel Male TRT Forum

Oh oh Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults Metformin and exercise independently improve insulin sensitivity and decrease the risk of diabetes. Metformin was also recently proposed as a potential therapy to slow aging. However, recent...

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While all my T levels across-the-board tanked after starting metformin, my IGF-1 levels sharply increased from a baseline of 250 to almost 400 after taking tesamorelin, ipamorelin/CJC-1295. I am not on testosterone therapy at the moment and feel that anyone that is on metformin should be hormonally optimized.

Were you using TRT when your T levels dropped?

No doubt this is important for the "natural" guy but this may not matter much to steroid using exogenous testosterone who is already experiencing H.P.T.A. suppression.

 

Were you using TRT when your T levels dropped?

No doubt this is important for the "natural" guy but this may not matter much to steroid using exogenous testosterone who is already experiencing H.P.T.A. suppression.

No TRT while on metformin. My take: caution to euglycemic men in using metformin when not on TRT.