Men with CAD More Likely to Receive TRT

Jinzang

Member
A study of Medicare records found that men with cardio artery disease (CAD) were more likelt to be on testosterone replacement therapy (TRT) than those who are not. I don't find thiis surprising, as men with low testosterone are more likely to have CAD than men with normal testosterone levels. But this press report seems to treat this result as some type of scandal and suggest tighter controls over the use of TRT.

Nancy E. Morden, MD, MPH, The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire, and colleagues examined Medicare data on millions of men aged at least 50 years between 2007 and 2016.

They found that as many as 7% of men used the hormone in certain parts of the United States, with the majority of prescriptions for off-label use. And spending on testosterone has been increasing annually, almost quadrupling from just over $100 million in 2007 to around $400 million in 2016. The research also shows that testosterone use is consistently higher among men with CAD than those without.

"Persistently higher testosterone use among patients with CAD suggests the need for more effective dissemination of label changes," the team writes.

"A robust prior authorization process could also help, as could rigorous evidence-based safety-review processes, richer shared-risk contracts, and patient education."
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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