Nelson Vergel
Founder, ExcelMale.com
Relationship of Coronary Artery Disease with Testosterone Level in Young Men Undergoing Coronary Angiography
Objective - This study aimed to investigate the relation of testosterone level with the extent of coronary artery disease (CAD) in young adult male undergoing coronary angiography.
Materials and methods - Medline databases (PubMed, Journal of Clinical Endocrinology and Metabolism, British Medical Journal, Journal of American College of Cardiology and European Heart Journal) and also materials available in the internet were searched. The search was performed in the electronic databases from 2014 to 2017. The initial search presented 127 articles of which 61 met the inclusion criteria.
The articles studied premature CAD, relation of testosterone level to CAD, and testosterone replacement therapy. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, adequate information, and defined assessment measures. Comparisons were made by structured review with the results tabulated.
Findings - In total, 61 potentially relevant publications were included. The studies indicate that the serum levels of both total and free testosterone were significantly lower in young males with CAD, and both were significantly correlated with the severity of CAD as assessed by Gensini score.
Conclusion - The low testosterone level is associated with both the incidence and severity of premature CAD in young adult males.
Badran HM, Soliman MA, Elmadbouh I, Ibrahim WA, El Masry SF. Relationship of coronary artery disease with testosterone level in young men undergoing coronary angiography. Menoufia Med J [serial online] 2019 [cited 2019 Apr 17];32:18-24. Available from: http://www.mmj.eg.net/text.asp?2019/32/1/18/256137
Objective - This study aimed to investigate the relation of testosterone level with the extent of coronary artery disease (CAD) in young adult male undergoing coronary angiography.
Materials and methods - Medline databases (PubMed, Journal of Clinical Endocrinology and Metabolism, British Medical Journal, Journal of American College of Cardiology and European Heart Journal) and also materials available in the internet were searched. The search was performed in the electronic databases from 2014 to 2017. The initial search presented 127 articles of which 61 met the inclusion criteria.
The articles studied premature CAD, relation of testosterone level to CAD, and testosterone replacement therapy. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, adequate information, and defined assessment measures. Comparisons were made by structured review with the results tabulated.
Findings - In total, 61 potentially relevant publications were included. The studies indicate that the serum levels of both total and free testosterone were significantly lower in young males with CAD, and both were significantly correlated with the severity of CAD as assessed by Gensini score.
Conclusion - The low testosterone level is associated with both the incidence and severity of premature CAD in young adult males.
Badran HM, Soliman MA, Elmadbouh I, Ibrahim WA, El Masry SF. Relationship of coronary artery disease with testosterone level in young men undergoing coronary angiography. Menoufia Med J [serial online] 2019 [cited 2019 Apr 17];32:18-24. Available from: http://www.mmj.eg.net/text.asp?2019/32/1/18/256137
