Nelson Vergel
Founder, ExcelMale.com
Blood Inflammatory Proteins and Psychological Symptoms during Testosterone Supplementation in Hypogonadal Men with the Metabolic Syndrome. -
See more at: http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2010.PART1.P8.P1-396#sthash.4Ui367a6.dpuf
Abstract:Introduction:Low testosterone levels and the metabolic syndrome (MetS) in men are associated with high levels of blood inflammatory proteins. There may be a direct link between inflammatory activation and low mood states.
Aim:To assess whether the beneficial effects of testosterone administration on subjective symptoms are determined by blood inflammatory protein levels.
Patients and Methods:In a randomized, placebo-controlled, double-blind trial 184 men suffering from both the metabolic syndrome and hypogonadism were included. At baseline C-reactive protein, interleukin 1b (IL-1b), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor–a (TNFa) were measured. In the present analysis, 67 men treated with parenteral testosterone undecanoate (TU; 1000 mg IM testosterone undecanoate; Nebido®) were included, with measurements at baseline, and after 18 (n=66), 30 (n=65, 42 (n=58), 54 (n=55), and 66 (n=51) weeks.
Main Outcome Measures:The Beck Depression Inventory (BDI), Aging Males' Symptoms (AMS) scale, and International Index of Erectile Function 5-item (IIEF-5) scale were analysed according to baseline inflammatory proteins using multilevel analysis.
Results:The 67 men were aged mean 52.3 years old (SD 10.0; range 35-69), with a mean body mass index of 35.8 kg/m[SUP]2[/SUP] (SD 4.5; range 24-54). Total testosterone level was 8.2 nmol/L (SD 4.4) at baseline, and normalized upon treatment. IL-1b, TNFa, and C-reactive protein decreased, while IL-6 and IL-10 did not change significantly. No associations were found with IL-1b, TNFa, and C-reactive protein. High baseline IL-6 and IL-10 levels were associated with higher BDI, AMS and lower IIEF scores over time.
Conclusions:High levels of IL-6 and the anti-inflammatory cytokine IL-10 were associated with more psychological discomfort in hypogonadal patients with the MetS during long-term TU administration.
- See more at: http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2010.PART1.P8.P1-396#sthash.4Ui367a6.dpuf
See more at: http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2010.PART1.P8.P1-396#sthash.4Ui367a6.dpuf
Abstract:Introduction:Low testosterone levels and the metabolic syndrome (MetS) in men are associated with high levels of blood inflammatory proteins. There may be a direct link between inflammatory activation and low mood states.
Aim:To assess whether the beneficial effects of testosterone administration on subjective symptoms are determined by blood inflammatory protein levels.
Patients and Methods:In a randomized, placebo-controlled, double-blind trial 184 men suffering from both the metabolic syndrome and hypogonadism were included. At baseline C-reactive protein, interleukin 1b (IL-1b), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor–a (TNFa) were measured. In the present analysis, 67 men treated with parenteral testosterone undecanoate (TU; 1000 mg IM testosterone undecanoate; Nebido®) were included, with measurements at baseline, and after 18 (n=66), 30 (n=65, 42 (n=58), 54 (n=55), and 66 (n=51) weeks.
Main Outcome Measures:The Beck Depression Inventory (BDI), Aging Males' Symptoms (AMS) scale, and International Index of Erectile Function 5-item (IIEF-5) scale were analysed according to baseline inflammatory proteins using multilevel analysis.
Results:The 67 men were aged mean 52.3 years old (SD 10.0; range 35-69), with a mean body mass index of 35.8 kg/m[SUP]2[/SUP] (SD 4.5; range 24-54). Total testosterone level was 8.2 nmol/L (SD 4.4) at baseline, and normalized upon treatment. IL-1b, TNFa, and C-reactive protein decreased, while IL-6 and IL-10 did not change significantly. No associations were found with IL-1b, TNFa, and C-reactive protein. High baseline IL-6 and IL-10 levels were associated with higher BDI, AMS and lower IIEF scores over time.
Conclusions:High levels of IL-6 and the anti-inflammatory cytokine IL-10 were associated with more psychological discomfort in hypogonadal patients with the MetS during long-term TU administration.
- See more at: http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2010.PART1.P8.P1-396#sthash.4Ui367a6.dpuf
